胸腺肽α_1对重症肺部感染患者T淋巴细胞亚群比例的影响  

Effect of thymosinα_1 on the percentage of T-lymphocyte subgroups in patients with severe: pulmonary infection

作　　者：侯立朝[1] 熊利泽[1] 尚磊[2] 霍婷婷[1] 陈绍洋[1] 胡文能[1] 王雅丽[1] 

机构地区：[1]第四军医大学西京医院麻醉科,西安市710032 [2]第四军医大学西京医院统计学教研室,西安市710032

出　　处：《中华麻醉学杂志》2006年第11期1005-1007,共3页Chinese Journal of Anesthesiology

基　　金：国家自然科学基金资助项目(30471675);陕西省科学技术厅攻关项目(2004K17-G15)

摘　　要：目的探讨胸腺肽α1对重症肺部感染患者T淋巴细胞亚群比例的影响。方法20例ICU重症肺部感染患者,年龄58-83岁,体重50-68 kg,随机分为对照组(A组)和胸腺肽α1组(B组),每组10例。B组在接受A组治疗方案的基础上加用胸腺肽α1。在治疗前1 d和治疗开始后1、2、3、4、5、6、7 d进行血常规检测,采用间接免疫荧光法测定外周血T淋巴细胞亚群CD3+、CD4+、CD8+比例,并观察患者临床症状、体征及胸部X片变化,进行疗效评价。结果治疗前2组白细胞计数(WBC)、中性粒细胞比例均高于正常值,CD3+、CD4+亚群比例均低于正常值;治疗开始后4-7 d后,B组WBC、中性粒细胞比例低于A组(P<0．05),CD3+、CD4+亚群比例及CD4+／CD8+比值高于A组(P<0．01);A组、B组感染控制总有效率分别为70％、90％,1月内病死率分别为40％、30％,组间比较差异均无统计学意义(P>0．05)。结论胸腺肽α1可增加重症肺部感染患者CD3+、CD4+淋巴细胞亚群比例及CD4+/ CD8+比值,有利于重症感染的控制。Objective To investigate the effect of thymosin α1 on the percentage of T-lymphocyte subgroups of peripheral blood in the patients with severe pulmonary infection. Methods Twenty patients with severe pulmonary infection according to the diagnostic criteria established by American Thoracic Society were randomly assigned to one of 2 groups （n = 10 each）： group A received regular treatment （control） and group B received thymosin α1 besides regular treatment. Venous blood samples were taken before （baseline） and on the 1st, 2nd, 3rd, 4th, 5th, 6th and 7th day of treatment for routine blood analysis including white blood cell （WBC） count and percentage of neutrophils and determination of the percentage of T-lymphocyte subgroups including CD3^＋ , CD4^＋ , and CD8^＋ lymphocytes using indirect immunoflurescence. The symptoms signs and chest-X ray were also checked. Results Before treatment the percentages of CD3^＋ and CD4^＋ were significantly lower than normal values while WBC counts and percentage of neutrophils were abnormally high in both groups. On the 4th -7th days of treatment the percentages of CD3^＋ and CD4^＋ and CD4^＋/CD8^＋ ratio were significantly higher in group B than in group A. The recovery of WBC count and percentage of neutrophils to normal level was also significantly faster in group B than in group A. The cure rate was 90% in group B and 70% in group A, but the difference was not statistically significant The mortality rate within one month after treatment was 40% in group A and 30% in group B. Conclusion Thymosin α1 can increase the percentages of CD3^＋ and CD4^＋ lymphocytes as well as CD4^＋/CD8^＋ ratio in patients with severe lung infection and may be beneficial to the control of severe infection.

关 键 词：胸腺激素类 免疫 细胞 T淋巴细胞亚群 肺炎 

分 类 号：R563.1[医药卫生—呼吸系统]