锌及络合锌抗银屑病作用的实验研究  

Effect of Zinc and Zinc-EDTA in inhibiting psoriasis

作　　者：付军[1] 崔晞[1] 刘振军[2] 刘娜[1] 丁勃 管益涛[4] 

机构地区：[1]山东大学公共卫生学院卫生检验教研室,山东济南250012 [2]山东省交通医院检验科,山东济南250031 [3]山东省药品检验所药理科,山东济南250012 [4]潍坊市疾病预防控制中心检验科,山东潍坊261041

出　　处：《山东大学学报（医学版）》2006年第12期1206-1208,共3页Journal of Shandong University:Health Sciences

基　　金：山东省交通厅资助课题(200424Y22)

摘　　要：目的:研究ZnCl2及Zn-EDTA对银屑病小鼠模型阴道上皮的有丝分裂作用。方法:使用昆明种雌性小鼠建立小鼠阴道上皮有丝分裂模型。将小鼠模型随机分为阴性对照组、阳性对照组,ZnCl2低、中、高剂量组、Zn-EDTA低、中、高剂量组。分别给药10 d。最后1次给药1 h后,腹腔注射秋水仙碱,脱颈椎处死小鼠。光学显微镜下观察细胞有丝分裂。结果:ZnCl2及Zn-EDTA的各剂量组均可显著抑制小鼠阴道上皮的有丝分裂(P<0.05),不同剂量的ZnCl2组间及Zn-EDTA组间与阳性对照组间差异无统计学意义。结论:ZnCl2及Zn-EDTA对小鼠模型阴道上皮有丝分裂的作用可能与抑制表皮增殖有关。Objective： To study the effect of Zinc and Zinc-EDTA in inhibiting psoriasis. Methods： Kunming mice of mitotic division model of vaginal epitheliums were randomly divided into eight groups： negative control, positive control, low, middle and high dosage of ZnCl2, and low, middle and high dosage of Zn-EDTA, and then they were momitored following ten days consecutive intragastrically administration of saline, Methotrexate, ZnCl2 and Zn-EDTA. And one hour after last administration, mice were administered colchicines by intraperitoneal injection and sacrificed by taking the cervical vertebrae off. The vaginal mitotic division was observed under light .microscope. Results： ZnCl2 or Zn- EDTA of different dosages could obviously inhibit the mitosis of vaginal epithelial cells （ P 〈 0.05）. No statistically significant was found between ZnCl2 or Zn-EDTA and positive control group. Conclusion： ZnCl2 or Zn-EDTA may inhibit the proliferation of epidermic cells in psoriasis animal model.

关 键 词：锌 螯合剂 银屑病 上皮细胞 阴道 小鼠 

分 类 号：R758.63[医药卫生—皮肤病学与性病学] R-332[医药卫生—临床医学]