tPA参与眼优势柱可塑性的研究进展  

Research advances in tissue-type plasminogen activator mediated ocular dominance column plasticity

作　　者：郑莎[1] 阴正勤[1] 

机构地区：[1]第三军医大学西南医院眼科,重庆市400038

出　　处：《眼科新进展》2007年第1期62-65,共4页Recent Advances in Ophthalmology

基　　金：国家杰出青年科学基金资助(编号:30025014);国家自然科学基金资助(编号:30672280)~~

摘　　要：哺乳动物的初级视皮层神经元具有眼优势,左、右眼优势的双眼细胞是按垂直于皮层表面的柱状交替排列的,即形成眼优势柱。在可塑性关键期内,初级视皮层对视觉输入的变化非常敏感,单眼剥夺将导致眼优势柱由被剥夺眼向开放眼移动。在此之前,双眼视觉输入的差异已经作为始动因素干扰兴奋-抑制平衡,产生一系列与可塑性相关的中介性信使物质,共同作用于组织型纤溶酶原激活剂,增强其蛋白水解效应,为视皮层的结构重组创造有利环境,从而在树突棘水平上,将快速的功能变化和经验依赖性神经环路的重构联系起来。Neurons in mammalian primary visual cortex have ocular dominance,and binocular neurons of right or left dominance respectively array in altemant columns perpendicular to the surface of cortex,namely ocular dominance columns. The primary visual cortex is especially sensitive to the changes in visual input over a critical period of plasticity, during which depriving one eye leads to a shift of ocular dominance columns from the deprived eye to the open eye. However ,before this happens, the difference between binocular visual inputs has already acted as a trigger for disturbing the excitement-inhibition balance and then producing series of intermediary messenger substances related to plasticity. All of these substances act on tissue-type plasminogen activators,and enhance its proteolytic activities, resulting in advantageous environment for structural reorganization of visual cortex. Therefore, rapid functional change is associated with reconstitution of experience-dependent neuronal circuits at the level of dendritic spines.

关 键 词：组织型纤溶酶原激活剂 眼优势柱可塑性 视皮层 突触 

分 类 号：Q42[生物学—神经生物学] R77[生物学—生理学]