糖尿病肾病动态血压与儿茶酚胺的相关性研究  

The Relationship of Urinary Catecholamines Excretion to Ambulatory Blood Pressure in Type 2 Diabetic Nephropathy Patients

作　　者：高继玲[1] 王秀玲[1] 高沛[1] 

机构地区：[1]新疆医科大学附属中医医院肾病科,新疆乌鲁木齐830040

出　　处：《农垦医学》2006年第4期246-248,共3页Journal of Nongken Medicine

摘　　要：目的:探讨尿儿茶酚胺(UCA)与2型糖尿病肾病(DN)动态血压(ABP)的关系。方法:用高效液相色谱-荧光检测器(HPLC-EDA)测定22例糖尿病肾病(Ш期)UCA浓度;昼、夜UCA包括去甲肾上腺素(NE)、肾上腺素(E)、多巴胺(DA),同时监测24 h ABP。结果:DN病人高血压者(HDM)及血压昼夜节律异常(反转及非反转)者24 hMBP与日、夜及24 h尿的NE、E水平之间,本资料提供的信息不能认为有相关性(P>0.05),UCA与24 h ABP各指标间亦不能认为有相关性(P>0.05)。HDM病人日夜DA水平明显低于正常人(P<0.05),差别有统计学意义。结论:交感神经肾上腺髓质系统活性与糖尿病肾病高血压及血压昼夜节律异常之间不能认为有相关性,外周DA水平降低有可能与糖尿病肾病变及高血压的发病有关。Objective. To study the relationship of urinary eatecholamines excretion to ambulatory blood pressure in type 2 diabetic nephropathy patients.Methods：Daytime and nighttime urinary catecholamines [c（UCA）] including norepinephrine （NE） , epinephrine （E） and dopemine （DA） were determined by HPLC- EDA in 22 hypertensive （HDM group） diabetic nephropathy subjects.24 h ambulatory blood pressure （ABP） profiles were recorded on the same day while urine samples were collected. Remits： Daytime NE and E, nighttime NE and E, 24 h NE and E in patients did not differ from subjects with paradoxical blood pressure rhythm and the remaining patients（P 〉 0, 05）. Canonical analysis showed no significant correlation between variables of UCA and indexes of 24 h ABP setting（P〉 0.05）. However another finding of this study showed that daytime DA and 24 h DA were significantly lower in HDM group than in nonpatients（P 〈 0.05）. Conclusion：Sympathoadrenomedullary systems seem to have little significant contribution to the pathogenesis of diabetic hypertension and dysregulation of circadian rhythm of blood pressure, Diabetic nephropathy might play an important role. Decreased peripheral DA might be correlated to diabetic hypertension and diabetic nephropathy.

关 键 词：2型糖尿病肾病 尿儿茶酚胺 动态血压 

分 类 号：R587.1[医药卫生—内分泌]