外周血IL-8mRNA表达与子宫内膜异位症关系  

Relationship between expression of IL-8 mRNA in peripheral blood and women with endometriosis

作　　者：孙琳[1] 万莉[2] 胡昌玲[2] 王健[1] 

机构地区：[1]安徽理工大学医学院妇产科护理学教研室,232001 [2]淮南市妇幼保健院妇产科

出　　处：《中国现代医药杂志》2006年第12期1-2,共2页Modern Medicine Journal of China

基　　金：安徽省教育厅自然科学基金项目(编号:2006KJ147C)

摘　　要：目的探讨外周血IL-8mRNA表达与子宫内膜异位症关系。方法用达那唑进行治疗,以Real-timePCR动态检测子宫内膜异位症患者外周血IL-8mRNA表达水平。结果子宫内膜异位症患者外周血IL-8mRNA水平为1.1339±0.1428,与对照相比,差异有显著性(P<0.01)。Ⅰ～Ⅱ期和Ⅲ期患者IL-8mRNA水平分别为1.1023±0.1371和1.1866±0.1543,相互比较差异无显著性(P>0.05)。达那唑治疗6个月后,外周血IL-8mRNA水平为1.0547±0.1299,与对照相比,差异无显著性(P>0.05)。结论子宫内膜异位症患者外周血IL-8mRNA表达增强,对子宫内膜异位症发生起促进作用。达那唑能抑制子宫内膜生长,降低由IL-8介导和参与的局部炎症反应。Objective To study the relationship between expression of IL-8 mRNA in peripheral blood and women with endometriosis and its clinical significance. Methods The women with endometriosis were treated with Danazol and the level of IL-8 mRNA in their peripheral blood was detected by Real-time PCR. Results The level of IL-8 mRNA in peripheral blood of women with endometriosis was 1.1339±0.1428. It was high significance between in endometriosis and without endometriosis （P〈0.01）. However, the level of IL-8 mRNA in endometriosis in stage of Ⅰ - Ⅱ and in stage of Ⅲ were 1.1023± 0.1371 and 1.1866±0.1543, few significance difference in two subgroups （P〉0.05）. After treatment of Danazol for six months, the expression of IL-8 mRNA in peripheral blood was 1.0547±0.1299, without significandy difference between in endometriosis and controls （P〉0.05）. Conclusion IL-8 mRNA is over expressed in peripheral blood of women with endometriosis and play key role in course of disease. The over expression of endometrium and local inflammatory reaction caused by IL-8 can be inhibited by Danazol therapy.

关 键 词：于宫内膜异位症 IL-8 Real—time PCR 达那唑 

分 类 号：R711.71[医药卫生—妇产科学]