转化生长因子β_1基因多态性与哮喘发病关系研究  

Study on TGF-β_1 Promoter Polymorphism in Asthmatics

作　　者：夏武[1] 周世良[2] 许萍[3] 李平[3] 王福新[3] 

机构地区：[1]九江学院附属医院呼吸科,江西九江332000 [2]南昌大学医学院,南昌330006 [3]南昌大学第四附属医院呼吸科,南昌330003

出　　处：《江西医学院学报》2006年第6期102-103,106,共3页Acta Academiae Medicinae Jiangxi

摘　　要：目的探讨转化生长因子β1(TGF-β1)基因多态性与哮喘发病之间的关系。方法采用聚合酶链反应-限制性片段长度多态性分析(PCR-RFLP)结合琼脂糖凝胶电泳方法,检测60例哮喘患者与30例健康对照者基因型。结果哮喘组基因型分布与健康对照组比较有显著性异(P<0.05);哮喘组与健康对照组T等位基因比较有显著性差异(P<0.05)。结论TGF-β1启动子C-509T多态性与哮喘发病可能有一定的相关性。Objective To investigate the possible relationship between TGF-β1 promoter polymorphism and asthma. Methods Sixty asthmatics and thirty healthy subjects were studied with the polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP） analysis. Results There were three genotypes （CC,CT,TT） in TGF-β1 promoter in the asthmatics and the healthy control subjects. The genotype frequencies between the asthmatics and the healthy control were significantly different （P〈0.05）. The T allele frequencies between the two groups were significantly different（P〈0. 05）. Conclusion This study indicates that the TGF-β1 promoter polymorphism is associated with the asthma phenotypes.

关 键 词：哮喘 转化生长因子Β1 基因 多态性 

分 类 号：R562.25[医药卫生—呼吸系统]