血塞通注射液体外溶血反应研究  

Study on hemolytic reaction of Xuesaitong injection in vitro

作　　者：陈金月[1] 秦耀春[1] 李海英[1] 文隽[1] 梁宇[2] 

机构地区：[1]广西中医学院第一附属医院药学部,广西南宁530023 [2]广西中医学院,广西南宁530001

出　　处：《药物不良反应杂志》2006年第6期414-417,共4页Adverse Drug Reactions Journal

摘　　要：目的:研究血塞通注射液对人血红细胞溶血度的影响,为其临床安全应用提供依据。方法:将血塞通注射液(含三七总皂甙100mg)稀释为25mg/ml,16.7mg/ml,及10mg/ml试液,用分光光度法和常规肉眼观察法测定试液所致人血红细胞溶血度。结果:浓度为25mg/ml及16.7mg/ml的试液引起溶血反应,但10mg/ml试液未致溶血反应。结论:血塞通注射液的溶血反应与其浓度有关。因此,血塞通注射应在使用前稀释至适宜的浓度,浓度<10mg/ml的溶液较为安全。Objective： To study the effect of Xuesaitong injection on hemolytic degree of human erythrocytes in order to provide evidence for its clinical safe use. Methods： The test solutions were prepared by diluting Xuesaitong injection （containing total saponin of Sanqi 100 mg） to 25 mg/ml, 1 6.7 mg/ml, and 10 mg/ml. The hemolytic degree of human erythrocytes caused by the test solutions was measured by spectrometry and routine macroseopy. Results： The hemolytic reaction was caused by the test solutions of 25 mg/ml and 16.7mg/ml, but it was not caused by the test solution of 10 mg/ml. Conclusion： The hemolytic reaction of Xuesaitong injection is related to its concentration. Therefore, Xuesaitong injection should bc diluted to appropriate conccntration before administration, and the concentration of solution no more than 10mg/ml is safe.

关 键 词：血塞通注射液 溶血反应 

分 类 号：R285[医药卫生—中药学]