松花粉对砷中毒大鼠的防护作用  

The protective effect of Pine Pollen on arsenic poisoning rats

作　　者：罗艳红[1] 黄晓敏[1] 韦文龙[2] 龚厚文[2] 陆兰芬[2] 韦玉脉[2] 韦耀东[1] 

机构地区：[1]右江民族医学院生物化学与分子生物学教研室,广西百色533000 [2]右江民族医学院

出　　处：《右江民族医学院学报》2007年第1期24-25,共2页Journal of Youjiang Medical University for Nationalities

基　　金：右江民族医学院重点课题资助项目2005(99号)

摘　　要：目的通过研究松花粉对砷中毒大鼠的血砷含量、血清谷胱甘肽过氧化物酶(GSH-PX)活性的影响,来检测松花粉对砷中毒大鼠的防护作用。方法将54只SD大鼠随机分为3组:即正常对照组、治疗组、中毒对照组。正常对照组饮用蒸馏水;治疗组、中毒对照组均隔天注射NaAsO2(8mg/kg)进行砷染毒,治疗组在砷染毒第15天后开始用松花粉灌胃(6.25g/kg)。至第45天,分别测各组血清中坤含量及GSH-PX活性。结果治疗组与正常对照组相比,两项指标差异均有显著性(P<0.05)。与中毒对照组比,两项指标差异有显著性(P<0.05)。结论松花粉能降低血砷含量,能提高GSH-PX活性,它有排血砷,提高抗氧化能力作用。Objective To explore the protective effect of Pine Pollen on arsenic （As） poisoning rats by measuring the content of serum As and the activity of Glutathione Peroxide （GSH- PX）. Methods 54 SD rats were randomly allocated to three groups, Group A （the normal group）, Group B （the treated group） and Group C （the poisoned group）. Group A were given distilled water from the beginning. Group B and group C were given injection with NaAsO2, 8mg/kg once every other day. After 15 days, Group B were intragastrically administrated with pine pollen, 6.25g/kg. Up to 45 days, the content of As and the activity of GHS- PX in serum were tested respectively. Results In comparison to Group B and Group A, the content of serum As in Group 3 increased remarkably （ P 〈 0.01）, while the activity of GSH- PX decreased apparently （ P 〈 0.05 or 0.01）. The comparison between Group B and Group A, the two indexes did not differed significantly （ P 〈 0.05）. Conclusion Pine Pollen can enhance the GSH- PX activity and increase, anti - oxidation ability by decreasing the content of blood As.

关 键 词：松花粉 砷中毒 大鼠 

分 类 号：R599.4[医药卫生—内科学]