急性肾盂肾炎大鼠模型的建立与观察  

Establishment and Observation of Rats Model with Acute Pyelonephritis

作　　者：周栋[1] 孙伟[1] 何伟明[1] 高坤[1] 陶兴[1] 陈继红[2] 

机构地区：[1]江苏省中医院,全国中医肾病医疗中心,江苏南京210029 [2]南京中医药大学,江苏南京210029

出　　处：《中国中医药信息杂志》2007年第1期30-32,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：江苏省中医药管理局资助课题(9989)

摘　　要：目的制作与人肾盂肾炎相似的动物模型,为临床治疗急慢性泌尿系感染性疾病打下实验基础。方法采用将大鼠单侧输尿管“半结扎”并同时向膀胱内注射大肠杆菌的方法造成急性肾盂肾炎的病理改变,并应用滋肾通关胶囊、三金片等进行干预观察。结果急性肾盂肾炎中剂量组、西药组、中西医结合组的大鼠体重增长明显,给药后大鼠的机体状况良好,药物治疗有效。结论急性肾盂肾炎的大鼠模型在生长状态、体重系数、肾重系数以及肾脏病理改变方面均与人肾盂肾炎发病相似,造模成功。Objective To made the animal model which is similar to the human pyelonephritis to strengthen the experimental basis for the therapy of acute urologic infectious disease. Method Using the method of semi-ligation of the ureter on single lateral and the injection of Enterobacter into the bladder to get pathologic transformation. Simultaneously, giving the different preparation of Zishentongguan Capsule, Sanjin Pills to intervene the models. Result Zishentongguan capsule middle dosage, western medicine treatment team had get obviously effect on rat body weight increasing, the drug treatment were validity. Conclnsion The rat model with the acute nephropyelitis is similar to the character in the break of human, which manifest on the appearance, mental condition, body weight coefficient, kidney weight coefficient and pathologic change of the kidney. Succeed in the model establishment.

关 键 词：急性肾孟肾炎 滋肾通关胶囊 大鼠 

分 类 号：R285.5[医药卫生—中药学]