兔急性肺水肿血浆中分子物质含量的变化  

Observation on the changes of middle molecular substance levels in the plasma of rabbits with acute pulmonary edema

作　　者：莫燕娜[1] 吉丽敏[1] 王丹妹[1] 何佟[1] 贝宁[1] 陈世民[1] 

机构地区：[1]海南医学院机能学实验室,海南海口571101

出　　处：《中国热带医学》2007年第1期33-34,共2页China Tropical Medicine

摘　　要：目的观察鬼急性肺水肿血浆中分子物质(Midme molecular substances,MMS)含量的变化。方法54只新西兰白兔随机分为实验组和对照组,实验组用大量输入生理盐水后加注0．1％肾上腺素生理盐水5mL/kg,复制出急性肺水肿；对照组只输入等量生理盐水,未注射肾上腺素。用改进的紫外吸收法分别测定实验前后血浆MMS值。结果实验组注射肾上腺素后出现肺水肿时与自身输液前相比,血浆MMS含量明显下降(P＜0．05)；与对照组相应时点相比,血浆MMS也明显下降(P＜0．01)。结论肾上腺素所致急性肺水肿可以使家兔血浆MMS含量降低,其机制可能与应激反应有关。Objective To observe the changes of middle molecular substance （MMS） levels in the plasma of rabbits with acute pulmonary edema. Methods Fifty - four rabbits were randomly divided into pulmonary edema group （group E） and control group （group C） ,each group consisted of 27 rabbits. Rabbits in group E were transfused with 0.1% epinephrine （5mg/kg body weight） after a large amount of 0.9% NaCl solution transfusion so as to induce acute pulmonary edema, while rabbits in group C were only transfused with equal amount of 0.9 % NaCl solution, without epinephrine. The concentration of MMS was estimated in each group by improved ultra - violet ray absorption method before and after saline transfusion, as well as 30min after epinephrine transfusion. Resuits The concentration of MMS in group E decreased significantly （ P 〈 0.05） after epinephrine transfusion. It also decreased significantly compared with the level of the rabbits in group C at the same time point （ P 〈 0.001 ）. Conclusion Acute pulmonary edema rabbits caused by epinephrine can reduce MMS levels in the plasma, a mechanism might be associated with stress reaction.

关 键 词：中分子物质 肾上腺素 肺水肿 

分 类 号：R561.4[医药卫生—呼吸系统]