氯沙坦与苯磺酸左旋氨氯地平治疗高血压病的疗效比较  

Efficacy and safety of Losartan versus Levoamlodipine besylate in patients with essential hypertension

作　　者：张臣[1] 刘翔[1] 钟广伟[2] 张丽波[1] 柴晓利[1] 

机构地区：[1]湖南省第二人民医院,湖南长沙410007 [2]中南大学湘雅医院,湖南长沙410008

出　　处：《现代中西医结合杂志》2007年第3期302-304,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的比较氯沙坦(科素亚)与苯磺酸左旋氨氯地平(施慧达)对原发性高血压的降压疗效及安全性。方法选取65例原发性高血压病患者,随机分为科素亚组(33例)和施慧达组(32例),均每天1次晨服相应药物,连续观察4周,每周固定一天上午测血压、心率和不良反应。用药前和用药后4周末检测血液生化指标。结果2组病例服药2周后,收缩压、舒张压均下降,同治疗前比较,有显著性差异(P均<0.05);服药4周后,收缩压、舒张压显著下降,同治疗前比较有显著性差异(P均<0.01)。科素亚组和施慧达组降压的有效反应率分别为91%和91%,无显著性差异(P>0.05);2组的不良反应率分别为9%和9%,无显著性差异(P>0.05)。结论科素亚和施慧达均能达到很好的临床降压效果,安全性好,不良反应率低。Objective It is to observe the antihypertensive efficacy and safety of Losartan（Cozaar） in patients with essential hypertension, and compared with Levoamlodipine besylate（Shihuida）. Methods 65 patients were randomly divided into two groups, 33 patients were treated with Losartan 50 mg per day for 4weeks, and another 32 patients received Shihuida 2.5 mg per day; A sitting BP and HR was measured ,and side effects were recorded every weeks, blood biochemical tests were made before and weekly after treatment. Results DBP and SBP were reduced at the second week（P 〈 0.05） in both two groups and the reduction at the fourth week was significant（ P 〈 0.01 ）. The total response rate was 91% for Cozaar group and 91% for Shihuida group（ P 〉 0.05）, side effectrate was 9 % and 9 % respectively（ P 〉 0.05）. Conclusion Both Cozaar and Shihuida decreased high BP with safety and less side effects.

关 键 词：氯沙坦 苯磺酸左旋氨氯地平 原发性离血压 

分 类 号：R544.1[医药卫生—心血管疾病]