被动吸烟对血管内皮舒张功能和血清TNF-α的影响  

Effect of passive smoke on vascular endothelial dilatation function and tumor necrosis factor-α in healthy young adults

作　　者：刘爱玲 刘广进[2] 李敏[3] 王文丽 陈伟 屈娟娟 

机构地区：[1]解放军第一五三中心医院,郑州450042 [2]河南工业大学医院 [3]河南省人民医院

出　　处：《中原医刊》2007年第1期1-2,共2页Central Plains Medical Journal

基　　金：河南省科技攻关计划资助项目（0496410036）

摘　　要：目的 探讨被动吸烟对健康青年人血管内皮舒张功能和血清肿瘤坏死因子（TNF-α）的影响。方法 采用超声肱动脉内径测量法，观察被动吸烟、主动吸烟及正常对照组各30例血流介导和硝酸甘油介导的肱动脉内径变化；同时测定各组外周血清TNF-α含量。结果 三组肱动脉内径基础值及硝酸甘油介导的肱动脉舒张差异均无统计学意义（P〉0．05），而血流介导的血管扩张被动吸烟组与正常对照组间差异有统计学意义（P〈0．01），与吸烟组比较差异无统计学意义（P〉0．05）。主、被动吸烟组TNF-α含量均高于正常组（P〈0．01），而两组间差异无统计学意义。结论 被动吸烟导致健康青年人群血管内皮舒张功能损伤可能与血清TNF-α增加有关。Objective To study effect of passive smoke on vascular endothelial dilatation function and tumor necrosis factor （TNF -α） in healthy young adults. Methods Brachial artery internal diameters were measured by ultrasonic. Observe changes of brachial artery internal diameters by flow - mediated and nitroglycerin - induced in passive smoker group, active smoker group, and control group （ each 30 cases）. And measure TNF-α of each group. Results Brachial artery basic internal diameters and brachial artery dilatation by nitroglycerin - induced were not significantly different among three groups （ P 〉 0.05 ）. Changes of brachial artery internal diameters by flow - mediated were significantly different between passive smoker group and control group （ P 〈0.01 ） ,while there was no significant difference between passive smoker group and active smoker group （ P 〉 0. 05）. TNF-α increased in passive smoker group and active smoker group, but had no significant difference between the two groups. Conclusion Passive smoking induces healthy young - adult to damage vascular endothelial dilatation function. Probably it relates to plasma TNF -α concentration increase.

关 键 词：高频超声 被动吸烟 主动吸烟 血管内皮舒张功能 肿瘤坏死因子-Α 

分 类 号：R544.1[医药卫生—心血管疾病]