益气回阳注射液对心肺复苏后大鼠血MDA及SOD的影响  

Impacts of Yiqihuiyang injection on MDA and SOD level in rats after resuscitation

作　　者：尹克春[1] 刘淑娟[1] 陈力[1] 周文斌[1] 兰丽红[1] 黄羽[1] 孙景波[1] 

机构地区：[1]广东省中医院心脏三科,广州510120

出　　处：《广东医学》2007年第1期21-23,共3页Guangdong Medical Journal

基　　金：广东省科技计划项目(编号:C30904);广州市科技立项项目(编号:2001-J-020-01)

摘　　要：目的观察益气回阳注射液对心脏骤停大鼠心肺复苏后血丙二醛(MDA)、超氧化物岐化酶(SOD)的影响。方法将50只清洁级雄性SD大鼠随机分为5组,正常对照组、模型组、肾上腺素组、益气回阳组、中西药合用组,每组10只。复制心脏骤停模型,在自主循环恢复30 m in后测定血MDA及SOD。结果模型组MDA含量高于正常对照组(P<0.01),SOD含量明显低于正常对照组(P<0.01);肾上腺素组、益气回阳组治疗后血SOD的含量高于模型组(P<0.01),MDA的含量低于模型组(P<0.01),肾上腺组+益气回阳组改善程度优于其他各组(P<0.05)。结论益气回阳注射液能减轻心脏骤停后血中MDA的生成,增加SOD活性,对心肺复苏后再灌注损伤有一定的治疗作用。Objective To investigate the impact of Yiqihuiyang injection on blood MDA and SOD level after cardiopulmonary resuscitation （CPR） in rats. Methods Fifty rats were randomly divided into five groups, each with 10 rats. The levels of blood MDA and SOD were measured. Results The concentration of MDA in model group was signifi- cantly higher than that of control group（ P 〈 0. 01 ）. The concentration of SOD in model group was significantly lower than that of control group（ P 〈 0. 01 ）. The concentration of MDA in adrenocorticoid group and Yiqihuiyang group was significantly lower than that in model group. The concentration of SOD in these group was significantly lower than that of model group（P 〈 0. 01 ）. The adrenocorticoid plus Yiqihuiyang group had a more significant improvement （P 〈 0. 05 ）. Conclusion Yiqihuiyang injection can attenuate reperfusion injury after CPR through reducing MDA and increasing SOD activity.

关 键 词：心脏骤停 超氧化物岐化酶 丙二醛 益气回阳注射液 

分 类 号：R285.6[医药卫生—中药学]