蛋白质/多肽药物聚乳酸/乳酸-羟基乙酸共聚物微球研究进展(英文)  

Recent advances in the preparation progress of protein/peptide drug loaded PLA/PLGA microspheres

作　　者：徐风华[1] 张强[2] 

机构地区：[1]解放军总医院药理药学研究室,北京100853 [2]北京大学药学院,北京100083

出　　处：《药学学报》2007年第1期1-7,共7页Acta Pharmaceutica Sinica

摘　　要：缓释微粒给药系统是蛋白质/多肽药物传输系统的一个重要研究方向,聚乳酸和乳酸-羟基乙酸共聚物是制备缓释微球最常用的载体材料。蛋白质/多肽药物聚乳酸/乳酸-羟基乙酸共聚物微球常用的制备方法包括溶剂萃取/挥发法(复乳法)、相分离法和喷雾干燥法。本文总结了微球制备中面临的难点如蛋白质/多肽药物稳定性、包封率、药物突释和药物吸附等问题,并综述了保持药物结构稳定性和生物活性、提高包封率、改善药物释放曲线等微球制备方法和进展。Sustained release drug delivery from microparticles is an excellent ahernative for daily protein/peptide drug administration protocol. Poly （ lactic acid） （ PLA ） and poly （ lactic-co-glycolic acid） （PLGA） are the most commonly used polymer carriers in the development of protein/peptide microspheres. Basically there are three preparation methods for PLA/PLGA microspheres： the solvent extraction/evaporation based multiple emulsion （W/O/W emulsion） method, the phase separation method and the spray drying method. The stability of the protein/pipetide loaded, encapsulation efficiency, and the burst effect of the microspheres are key problems usually met in the preparation of microspheres. In this review the preparation techniques and progress in the development of protein/pipetide microspheres which aimed to stabilize protein/peptide structural integrity, keep the bioactivity of drugs, increase the encapsulation efficiency and improve the release profile were summarized and evaluated.

关 键 词：蛋白质 多肽 聚乳酸 乳酸-羟基乙酸共聚物 微球 

分 类 号：R977.6[医药卫生—药品]