乙环唑的合成  

Synthesis of Etaconazole

作　　者：翁建全[1] 卜宇岚[2] 沈德隆[1] 

机构地区：[1]浙江工业大学化学工程与材料学院,杭州310032 [2]湖南公安高等专科学校,长沙410138

出　　处：《农药》2007年第1期27-28,共2页Agrochemicals

摘　　要：将2,4-二氯苯乙酮与溴发生取代反应生成ω-溴-2,4-二氯苯乙酮,然后在催化剂对甲基苯磺酸存在下,ω-溴-2,4-二氯苯乙酮与1,2-丁二醇发生脱水反应得到2-(2,4-二氯苯基)-2-溴甲基-4-乙基-1,3-二氧戊环,最后缩酮化合物与三氮唑钠缩合得到乙环唑。反应总收率达到70.4%(以2,4-二氯苯乙酮计),产品含量96%。产物结构经IR、1HNMR和MS表征。Etaconazole was synthesized by bromating 2,4-dichloroacetophenone with Br2, and then dehydrating between the resulted ω-Bromo-2,4-dichloroacetophenone and 1,2-butanediol with p-toluenesulfonic acid as catalyst, followed by condensation the obtained 2-（2,4-dichlorophenyl）-2-bromomethyl-4-ethyl-1,3-dioxolane with 1,2,4-triazole Na salt. The total yield of etaconazole was as high as 70.4% and its purity was 96%. The structure of the product was confirmed by IR,^1H NMR and MS.

关 键 词：ω-溴-2 4-二氯苯乙酮 2-(2 4-二氯苯基)-2-溴甲基-4-乙基-1 3-二氧戊环 乙环唑 合成 

分 类 号：TQ455.4[化学工程—农药化工]