混旋扁桃酸衍生物的高效液相色谱法拆分  

Chiral Stationary Phase for Separation of Enantiomorph Derivatives of Mandelic acid in High Performance Liquid Chromatography

作　　者：薛洪宝[1] 刘庆彬[2] 张福军[2] 张占辉[2] 

机构地区：[1]蚌埠医学院,安徽蚌埠233000 [2]河北师范大学化学化工研究所,河北石家庄050091

出　　处：《河北化工》2007年第1期43-45,64,共4页Hebei Chemical Industry

基　　金：河北省自然科学基金资助重点项目(No.B2005000151)

摘　　要：采用天然手性中心多糖类手性反相色谱固定相填料,高氯酸钠水溶液和乙腈为流动相,在不同的流动相比例下拆分多种扁桃酸衍生物,从而得出拆分手性化合物的规律性,与手性碳相连的基团越大,越容易被拆分。Using reversed-phase on chiral-cel OD-R, a polysaccharide-derived loading material chiral stationary phase, sodium perchlorate monohydrate solution and acetonitrile--mobile phase of high performance liquid chromatography separate enantiomorph derivatives of mandelic acid by adjusting different proportion of mobile phase. In this process, the regularity of chiral compounds that chiral center connect with long carbon chains directly can be more easy separated than that of chiral center connect with short carbon chains.

关 键 词：液相色谱 手型固定相 对映体混合物 手性分离 扁桃酸 

分 类 号：TQ245.4[化学工程—有机化工] O641.6[理学—物理化学]