被动型Heymann肾炎大鼠肾小球基底膜电荷屏障的变化  

The Changes in Anionic Sites in Glomerular Basement Membrane in Passive Heymann Nephritic Rats

作　　者：陈书芬[1] 阴东平[2] 张建民[2] 尹克铮[2] 万美玲 

机构地区：[1]南京医科大学附属南京第一医院肾内科 [2]南京铁道医学院附属医院

出　　处：《南京铁道医学院学报》1996年第4期240-243,共4页Journal of Nanjing Railway Medical College

摘　　要：目的：检测被动型Ｈｅｙｍａｎｎ肾炎（ＰＨＮ）肾小球基底膜电荷屏障的变化。方法：将含肾小管抗体的抗血清腹腔注射于大鼠体内建立被动型Ｈｅｙｍａｎｎ肾炎（ＰＨＮ）模型。用聚乙烯亚胺作为示踪剂，在电镜下观察ＰＨＮ大鼠肾小球基底膜阴离子位点的变化。结果：ＰＨＮ大鼠肾小球基底膜阴离子位点明显减少。结论：在ＰＨＮ中。Objective :To investigate the glomerular charge barrier change in passive heymann nephritic(PHN) rats.Method :Polyethyleneimine(PEI) was used as tracing marker to observe the anionic sites in glomerular basement membrane(GBM) by electronmicroscope.Result :Anionic sites in GBM of PHN rats were fewer than those of normal rats.Conclusion :There may be a glomerular charge barrier damage in PHN that causes proteinuria.

关 键 词：肾炎 PHH 肾小球基底膜 电荷屏障 聚乙烯亚胺 

分 类 号：R692.3[医药卫生—泌尿科学]