基于MRS定量检测γ-氨基丁酸浓度的序列设计及优化  

Design and optimization of pulse sequence for quantitative measurement of γ-aminobutyric acid concentration using MR spectroscopy

作　　者：陈耀文[1] 梁兵[1] 沈智威[2] 叶盛[1] 贺健康[1] 吴仁华[2] 

机构地区：[1]汕头大学工学院电子系,515063 [2]汕头大学医学院第二附属医院医学影像教研室,515041

出　　处：《国际生物医学工程杂志》2006年第6期325-329,共5页International Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(30570480)

摘　　要：目的设计及优化用于定量检测γ-氨基丁酸浓度的磁共振频谱脉冲序列。方法对MRS序列进行深入研究,基于乘积算符理论和模拟软件讨论定量检测GABA的方案。结果通过MRUI软件的模拟可知此脉冲序列压制了δ3.0处的Cr高信号,成功地显示了被覆盖的GABA信号,达到了设计的目的。结论设计及优化了脉冲序列,研究了提高检测效率及稳定性的方法,为后续编程实现脉冲序列进行理论准备。Objective To design and optimize the MRS pulse sequence which used to measure gemmaaminobutyric acid（GABA） in vivo. Methods In-depth research for the MRS sequence was carried out and a theoretical analysis and simulation by software using product-operator algebra for the design and optimization of pulse sequence was discussed. Results Through the simulation of MRUI software, Cr signal at 83.0 was seen to be suppressed and the weak GABA signal was displayed clearly. Conclusion The sequence was designed and optimized. Method to increase the efficiency and the stability of the measurement was studied. Our research gives theoretical preparation for the coming programming work.

关 键 词：磁共振频谱 定量检测 Γ-氨基丁酸 谱编辑 脉冲序列 优化 

分 类 号：R310[医药卫生—基础医学]