通脉活血灵胶囊中大黄酚在大鼠血浆中的浓度及药代动力学研究  

Determination of chrysophanol from Tongmaihuoxueling Capsules in rat's plasma and study on its pharmacokinetics

作　　者：李兰芳[1] 张勤增[1] 解丽君[1] 杨凤旭[2] 

机构地区：[1]河北省医学科学院,河北石家庄050021 [2]河北医科大学中医学院中药系,河北石家庄050021

出　　处：《河北医学》2006年第12期1207-1209,共3页Hebei Medicine

摘　　要：目的:观察大鼠口服通脉活血灵胶囊后,其效能成分大黄酚在大鼠体内的药动学过程。方法:大鼠单次灌服通脉活血灵胶囊,用反相高效液相法测定不同时间的血药浓度,采用DAS2.0药动学软件拟合处理该药的药动学参数。结果:通脉活血灵胶囊中大黄酚在大鼠体内的药动学参数:T1/2,αT1/2,βAUC(o-∞),K10,K12,K21,Tmax,Cmax分别为:1.054h,4.197h,2479.555 mg/L,0.077 1/h,0.222 1/h,0.407 1/h,0.5h,230.58 mg/L。结论:单次灌服通脉活血灵胶囊后,大黄酚在大鼠体内的药动学过程符合开放型二室模型,吸收快,消除慢,同服用单味大黄后大黄酚在家兔体内的药动学过程有一定的差异。Objective： To study the pharmacokinetics of chrysophanol in rats after ig administration of Tongmaihuoxueling capsules （TC ）. Methods： The concentrations of chrysophanol in plasma were determined by RP - HPLC method after single ig administration of TC. The parameters of pharmacokinetics were compu- ted by DAS 2.0 program. Results： The pharmacokinetic parameters of chrysophanol from TC in rats were as follows ： T1/2 ct0 Tl/213, AUC （o - ∞ ） , K10, K12, K21, Tmax, Cmax; Their value were respectively 1. 054h,4. 197h,2479.555 mg/L,0.077 l/h,0.222 l/h,0.407 l/h,0.5 h,230.58 mg/L. Conclusion： After single ig administration of TC in rats, the concentration - time curves of chrysophanol in plasma fitted a two - compartment open model. The pharmacokinetic of chrysophanol from TC shows a rapid absorption and slow elimination process in rats, which is different from the pharmacokinetic of chrysophanol after ig administration of rhubarb in rabbits.

关 键 词：通脉活血灵胶囊 大黄酚 血药浓度 HPLC 

分 类 号：R285.5[医药卫生—中药学]