多囊性卵巢综合征患者血清C反应蛋白水平与临床因素相关性的分析  

Serum C-reactive protein and its relationship with clinic factors in patients with polycystic ovary syndrome

作　　者：胡卫红[1] 乔杰[1] 王丽娜[1] 张小为[1] 李美芝[1] 

机构地区：[1]北京大学第三医院妇产科

出　　处：《中国妇产科临床杂志》2007年第1期44-47,57,共5页Chinese Journal of Clinical Obstetrics and Gynecology

基　　金：国家自然科学基金(30570872)资助

摘　　要：目的探讨多囊性卵巢综合征(PCOS)患者血清中C反应蛋白(CRP)的浓度与临床因素的相关性。方法对90例PCOS患者及20例正常对照组应用免疫比浊法检测血清中CRP水平,同时应用生化法检测血清中总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白-胆固醇(LDL-C)及高密度脂蛋白-胆固醇(HDL-C);对PCOS患者进行葡萄糖耐量(OGTT)及胰岛素释放实验。根据体重指数(BMI),PCOS患者分为肥胖组48例(BMI≥25kg/m2),非肥胖组42例(BMI<25kg/m2)。结果①肥胖及非肥胖PCOS患者logCRP均明显高于正常对照组(P<0.05),肥胖PCOS患者logCRP明显高于非肥胖PCOS患者(P<0.05);②Pearson相关分析显示,logCRP与BMI、HOMA-IR呈正相关(P<0.05);与HDL-C和胰岛素敏感指数(ISI)呈负相关(P<0.05)。排除BMI影响后的偏相关分析显示,logCRP与HOMA-IR呈正相关(P<0.05),与ISI呈负相关(P<0.05)。结论PCOS患者机体内可能存在着一种慢性炎症状态;PCOS患者血清CRP水平的升高可能是预测2型糖尿病的一个危险因子。Objective To measure serum C - reactive protein （CRP） levels and analyze its associations with clinical factors in patients with polycystic ovary syndrome （PCOS）. Methods Ninety PCOS women and 20 ovulating healthy women with body mass index （BMI） 〈25 kg/m^2 as controls were recruited. PCOS women were divided to two groups： 48 BMI≥25 kg/m^2 patients as obese group; 42 BMI〈25 kg/mz as non-obese group. Serum CRP was assayed by immunoturbidimetry. And triglycerides （TG）, total cholesterol （TC）, high density lipoprotein cholesterol （HDL-C） and low density lipoprotein cholesterol （LDL- C） were measured. Oral glucose tolerance test （OGTT） and insulin sensitivity were also assessed in PCOS patients. Results O Obese and non-obese PCOS group presented markedly higher IogCRP than controls group （both P〈0.05）, and the IogCRP is higher in the obese PCOS group than non--obese PCOS group （P〈0. 05）. ②Univariate analysis revealed that IogCRP was significantly and positively correlation with BMI and HOMA- IR （P〈0. 05）; LogCRP was significantly and negatively correlation with HDL- C and ISI （P〈0. 05） in patients with PCOS. Partial correlation showed that IogCRP was correlation with HOMA- IR （P〈0. 05）, and IogCRP was significantly and negatively correlation with ISI （P〈0. 05） in patients with PCOS. Conclusions Chronic inflammation maybe exists in patients with PCOS. CRP may be a predictor of future type 2 diabetes mellitus in PCOS patients.

关 键 词：多囊卵巢综合征(PCOS) C-反应蛋白(CRP) 慢性炎症 

分 类 号：R711.75[医药卫生—妇产科学]