凝胶体系中混合羧酸钾对草酸钙结晶的调控作用  

Modulation of Mixed Potassium Carboxylates on Crystallization of Calcium Oxalate Crystals in Gel System

作　　者：柳一鸣[1] 袁欢欣[2] 欧阳健明[2] 

机构地区：[1]湖南理工学院化学化工系,岳阳414000 [2]暨南大学生物矿化与结石病防治研究所,广州510632

出　　处：《无机材料学报》2007年第1期75-78,共4页Journal of Inorganic Materials

基　　金：国家自然科学基金(20471024);广东省科技攻关项目(2005B30701003);国家自然科学基金重点项目(20031010)

摘　　要：酒石酸钾(K2tart)、柠檬酸钾(K3cit)和乙二胺四乙酸钾(K2edta)均可用于防治草酸钙(CaOxa)结石,但它们各有其优缺点．本文采用双扩散法比较研究了这3种羧酸钾以不同比例两两混合时对CaOxa结晶的影响,结果表明,混合剂或者能够诱导更多的二水草酸钙(COD)和三水草酸钙(COT)晶体,或者减小一水草酸钙(COM)的尺寸,K2edta-K3cit混合剂还能诱导(100)晶面减小、螺旋式生长的COD晶体,该COD与肾小管细胞膜的粘附力较弱．这些均有利于抑制草酸钙结石形成,表明混合剂的防石效果优于单一钾盐．Potassium tartrate （K2tart）, potassium citrate （K3cit） and dipotassium ethylene diamine tetraacetate （K2edta） can be used to prevent and cure calcium oxalate （CaOxa） stones. It was investigated that the modulation of the mixed potassium carboxylates of these three compounds on the crystallization of CaOxa in gel system by a double diffusion technique. The results show that the mixed carboxylates can either induce more calcium oxalate dihydrate （COD） and trihydrate （COT） crystals, or decrease the size and special surface area of calcium oxalate monohydrate （COM）. For the mixture of K2edta and K3cit, the twisted COD crystals are grown. These twisted COD crystals look like the morphology of the COD grown in healthy human urine and have a less （100） crystal face, which can decrease the retention and adhesion of COD crystals on the surface of renal tubular cells. All these effect can inhibit the formation of CaOxa stones. It demonstrates that the mixed potassium carboxylates have better inhibitive effect than any of the single.

关 键 词：生物矿化 草酸钙 凝胶 羧酸钾 

分 类 号：O611[理学—无机化学] TQ115[理学—化学]