乙型肝炎病毒血清标志物联合检测的意义  

Combined detection and its significance of serological markers in 141 cases of HBV

作　　者：张国元[1] 王永富[2] 凡瞿明[1] 周彤[1] 张金花[1] 何兰[1] 邓仁兵[1] 程吉兵[1] 赖猛[1] 

机构地区：[1]川北医学院附属医院检验科 [2]川北医学院医学检验系2001级,四川南充637000

出　　处：《检验医学与临床》2007年第1期1-1,3,共2页Laboratory Medicine and Clinic

摘　　要：目的探讨联合检测乙型肝炎(下称乙肝)病毒血清标志物两对半定量、乙肝病毒(HBV)DNA定量与前S2抗原对乙肝患者诊断和预后的意义。方法分别使用酶联免疫吸附试验(ELISA)法、荧光定量PCR(FQ-PCR)和化学发光微粒子免疫分析技术(CMIA)对141例乙肝患者的乙肝病毒前S2抗原(Pre-S2)、乙肝病毒DNA(HBV-DNA)、乙肝两对半进行定性和(或)定量检测。结果137例HBsAg阳性患者中Pre-S2阳性119例,HBeAg阳性69例,HBV-DNA阳性84例,阳性率Pre-S2>HBV-DNA>HBeAg。结论联合检测乙肝病毒血清标志物两对半、HBV-DNA定量及Pre-S2,可以更全面地反映临床HBV感染、复制、传染性及抗病毒治疗效果的状况。Objective To explore the clinical significance of detecting serological markers, HBV and Pre-S2 together. Methods 141 samples from the patients with HBV were tested for the serological markers, HBV-DNA and Pre-S2 by CMIA,FQ-PCR and ELISA individually. Results The HBsAg in 137 cases and the Pre-S2 in 119 cases were positive, the HBeAg in 69 cases and HBV-DNA in 84 cases were positive. The positive rate of the Pre-S2 was highest in three, and the positive rate of the HBeAg was lowest. Conclusion The united detection of serological markers, HBV-DNA and Pre-S2 can be used to reflect HBV infection,duplication, contagiousness and the curative effect of anti-virus therapy.

关 键 词：乙型肝炎病毒 前S2蛋白抗原 HBV-DNA 

分 类 号：R512.62[医药卫生—内科学]