五氟苯甲酸的制备  

Preparation of 2,3,4,5,6-Pentafluorobenzoic Acid

作　　者：葛雅莉[1] 林原斌[1] 苏琼[1] 尹建湘[1] 赵辉[1] 

机构地区：[1]湘潭大学化学学院,湖南湘潭411105

出　　处：《中国医药工业杂志》2007年第1期14-14,21,共2页Chinese Journal of Pharmaceuticals

摘　　要：五氯苄腈与活化的氟化钾在环丁砜中进行氟交换制得五氟苄腈,再经50%硫酸水解得到司帕沙星等氟喹诺酮类抗菌药原料五氟苯甲酸,总收率约45%。2,3,4,5,6-Pentafluorobenzoic acid was synthesized from 2,3,4,5,6-pentachlorobenzonitrile by fluorine exchange in sulfolane to give 2,3,4,5,6-pentafluorobenzonitrile, which was subjected to hydrolysis by 50% sulfuric acid with an overall yield of about 45 %.

关 键 词：五氟苯甲酸 中间体 制备 

分 类 号：O625.53[理学—有机化学]