洛莫司汀脂质体的制备  

Preparation of Lomustine Liposomes

作　　者：施菁[1] 沈圆圆[2] 金一[2] 邱利焱[2] 上官盈盈[1] 

机构地区：[1]浙江医学高等专科学校,浙江杭州310053 [2]浙江大学药学院,浙江杭州310031

出　　处：《中国医药工业杂志》2007年第1期27-29,共3页Chinese Journal of Pharmaceuticals

摘　　要：采用逆相蒸发法制备洛莫司汀脂质体。采用正交试验法优化处方及工艺。优化后的脂质体外观圆整而均匀,平均包封率为(85.2±1.0)%,94.9%以上的脂质体粒径在100nm以下,平均粒径为(47.5±3.1)nm。Lomustine lipesomes were prepared by the reversed-phase evaporation method. The orthogonal experimental design was applied to optimize the preparation. It was showed that the lomustine fiposomes were spherical and integrated with the mean entrapment efficiency of （85.2± 1.0） %. The size of 94.9% particles was smaller than 100nm with the mean value of （47.5 ±3.1） nm.

关 键 词：洛莫司汀 脂质体 包封率 逆相蒸发法 

分 类 号：R944.9[医药卫生—药剂学]