CpG-寡核苷酸与支气管哮喘  

CpG Oligodeoxynucleotides and asthma

作　　者：谢世光[1] 蔡柏蔷[1] 

机构地区：[1]中国医学科学院中国协和医科大学 北京协和医院呼吸科,100730

出　　处：《国际呼吸杂志》2007年第1期16-18,共3页International Journal of Respiration

摘　　要：Th1／Th2失衡是支气管哮喘的重要免疫学发病机制，近年在支气管哮喘的发病机制中取得较大进展，CD4^＋T辅助细胞按其分泌的细胞因子不同分为Th1和Th2细胞，Th1反应可以抑制Th2反应，抑制气遭慢性炎症，含有未甲基化CpG结构的寡核苷酸是近年研究较多的一种调节Th1／Th2平衡的免疫制剂，本文就其调节Th1／Th2平衡在支气管哮喘治疗中的应用前景作一综述。Asthma is associated with the Th1/Th2 response imbalance, skewing of immune responses towards a Th2 phenotype, and resulting in eosinophilic inflammation, airway hyperresponsiveness and airway remodeling. Recent epidemiological studies suggest that reduced early-life exposure to strong Th1 stimuli in industrialized counties has skewed the Th1/Th2 balance towards Th2 responses. Recent studies also show that Oligodeoxynucleotides （ODN） containing sequence motifs centered on unmethylated CG dinucleotides （CpG-ODN） are immunostimulatory. CpG-ODN can suppress Th2-mediated eosinophilic inflammation, airway hyperresponsiveness and airway remodeling in murine asthma. CpG ODN may be an effective immunomodulatory agent in the treatment, and possibly prevention, of asthma.

关 键 词：哮喘 寡核苷酸 

分 类 号：R5[医药卫生—内科学]