CD4^＋CD25^＋调节性T细胞在哮喘发生发展中的作用研究进展  

The role of CD4^＋ CD25^＋ regulatory T cell in the pathogenesis of asthma

作　　者：张倩[1] 殷凯生[1] 

机构地区：[1]南京医科大学第一附属医院呼吸科,210029

出　　处：《国际呼吸杂志》2007年第1期37-40,共4页International Journal of Respiration

基　　金：国家自然科学基金青年科学基金项目（30400191）;国家自然科学基金自由申请项目（30570797）

摘　　要：支气管哮喘被普遍认为是因Th1／Th2失衡，由过度激活的Th2细胞介导的气道炎症性疾病。然而，Th1／Th2理论并不能充分阐明哮喘的发病机制。近几年来，越来越多的证据显示调节性T细胞在哮喘的发生发展中起到很重要的作用，CD4^＋CD25^＋调节性T细胞作为调节性T细胞的一种亚型成为目前研究的热点。本文就近来对CD4^＋CD25^＋调节性T细胞研究的进展及其与哮喘的关系作一综述。It is generally considered that asthma is a disorder of airway inflammation which is mediated by Th2 excessively activated because of the imbalance of Th1/Th2 paradigm. However, the pathogenesis of asthma couldn＇t be interpreted with Th1/Th2 paradigm sufficiently. Recently, more and more evidence highlight the substantial role of regulatory T cell in the nosogenesis of asthma. As a subtype of regulatory T cell, CD4^＋ CD25^＋ regulatory T cell is focused on and widely researched. This review will explore the relation between CD4^＋ CD25^＋ regulatory T cell and asthma, and the progress of study of CD4^＋ CD25^＋ regulatory T cell.

关 键 词：调节性T细胞 哮喘 TOLL样受体 

分 类 号：R5[医药卫生—内科学]