一种新型可降解缓释微系统的优化设计  

The Optimization Design of a Novel Biodegradable Polymer Micro-Device

作　　者：杨战孝[1] 陈天宁[1] 

机构地区：[1]西安交通大学机械工程学院,西安710049

出　　处：《北京生物医学工程》2006年第6期579-582,共4页Beijing Biomedical Engineering

基　　金：国家863计划(2003AA404170);国家自然科学基金(50375116)资助

摘　　要：多腔体的微型可降解高分子聚合物药物缓释系统是一种新型给药技术,其载体结构是利用MEMS工艺的制备特点,结合药物释放的要求和高分子聚合物生物降解特性进行设计的。为了达到该系统在体内长期释药的性能,对释药载体的结构进行参数优化十分必要。文中建立了具有多腔体的微型可降解高分子聚合物给药载体的释药模型以及载体的结构优化模型,仿真及优化结果表明该模型可以用来指导基于可降解材料的结构优化设计。The biodegradable controned-release system with large array of micro chambers use a new controlled drug delivery technology. The structure of the system is designed using the MEMS technology, combining the drug release condition and the biodegradable characteristic of the polymer. It is necessary to optimize the structure for the long-term drug delivery. This paper found the simulated and optimized modeling for the drug delivery from the biodegradable contrulled-release system. The results indicate that the simulated and optimized modelings can be used to design the structure baaed on the degradable polymer.

关 键 词：药物缓释系统 释药模型 仿真优化 

分 类 号：R318.6[医药卫生—生物医学工程]