水杨醛缩天冬酰胺Schiff碱稀土配合物的合成与抗·O_2^-生物活性  

Synthesis and ·O_2^- Scavenging Bioactivity of Rare Earth Complexes with N-(Salicylaldehyde) Asparagine Schiff Base

作　　者：易国斌[1] 陈德余[2] 

机构地区：[1]广东工业大学轻工化工学院,广东广州510006 [2]浙江大学化学系,浙江杭州310027

出　　处：《中国稀土学报》2006年第6期750-754,共5页Journal of the Chinese Society of Rare Earths

基　　金：广东省自然科学基金团队项目(04205301)资助

摘　　要：合成了水杨醛缩天冬酰胺的系列稀土配合物,通过熔点测定、元素分析、摩尔电导率、磁化率、TG-DTA、UV、IR、1H-NMR、EPR谱等对配体及配合物的组成进行了表征,得到配合物的可能组成为RE3(AS)2(NO3)5.3C2H5OH.H2O。磁化率数据表明配合物为三中心结构,摩尔电导率数据表明配合物为1∶2型电解质,即2个NO3-在外界,3个NO3-在内界。TG-DTA,IR,1H-NMR等分析表明水分子参与配位,CO2-,NO3-均以双齿配位,Nd3+的顺磁位移效应使与之相邻质子的1H-NMR位移值增大。抗超氧阴离子自由基(.O2-)实验表明,配合物具有显著的抗.O2-生物活性。Seven rare earth complexes with N-（salicylaldehyde） asparagine Schiff base were synthesized. Their composition was characterized by elemental analysis, melting point, molar conductivity, magnetic susceptibility, TG-DTA, UV spectra, IR spectra and ^1H- NMR spectra. General formula of the complexes is probably written as RE3 （ AS ）2 （ NO3 ）5 · 3C2H5OH · H2O. The complexes are proved to be trinuclear by magnetic susceptibility and 1 ： 2 type electrolyte by molar conductivity, that is to say, three NO3^- ions are coordinated to RE^3＋ ion and the other two are not. It is suggested that H2O is coordinated with RE^3＋ ion, both CO2^- and NO3^- are bidentate coordinated, and all three C2H5OH are free. The complexes show strong ·O2^- scavenging bioactivity.

关 键 词：水杨醛缩天冬酰胺 稀土配合物 表征 抗·O2^-生物活性 

分 类 号：O614.33[理学—无机化学]