Voltammetric studies on the interaction of amikacin with methyl blue and its analytical application  

作　　者：Xue Liang Wang Zhang Yu Yu Kui Jiao 

机构地区：[1]Department of Chemistry and Chemical Engineering, Heze University, Heze 274015, China [2]College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China

出　　处：《Chinese Chemical Letters》2007年第1期94-96,共3页中国化学快报（英文版）

基　　金：The work was supported by the National Natural Science Foundation of China （No. 20375020）.

摘　　要：A new method to determine the concentration of amikacin （AMK） using methyl blue （MB） as electrochemical probe was developed in this paper. In pH 4.5 Britton-Robinson （B-R） buffer solution, the MB reacted with AMK to form ion association complexes, which led to the reductive peak current of MB at -0.275 V （versus SCE） to decrease, and the decreases were linear with the concentration of AMK in the range of 1.0-60.0 mg/L, the regression of equation is AIp （hA） = -8.48 ＋ 102.36c （rag/L）, correlation coefficient yis 0.997. The conditions for determining the concentration of AMK using linear sweep voltammetry （SLV） were optimized. The method was used to determine the content of amikacin commercially available with satisfactory results.A new method to determine the concentration of amikacin （AMK） using methyl blue （MB） as electrochemical probe was developed in this paper. In pH 4.5 Britton-Robinson （B-R） buffer solution, the MB reacted with AMK to form ion association complexes, which led to the reductive peak current of MB at -0.275 V （versus SCE） to decrease, and the decreases were linear with the concentration of AMK in the range of 1.0-60.0 mg/L, the regression of equation is AIp （hA） = -8.48 ＋ 102.36c （rag/L）, correlation coefficient yis 0.997. The conditions for determining the concentration of AMK using linear sweep voltammetry （SLV） were optimized. The method was used to determine the content of amikacin commercially available with satisfactory results.

关 键 词：Methyl blue Amikacin  Voltammetry 

分 类 号：R927.2[医药卫生—药学] R978.12