γ型干扰素、CD4^+CD25^+调节性T细胞与自身免疫病  

Interferon-gamma and CD4^+ CD25^+ regulatory T cells in autoimmune diseases

作　　者：马海霞[1] 刘光伟[1] 赵勇[1] 

机构地区：[1]中国科学院动物研究所生物膜与膜生物工程国家重点实验室移植生物学研究组,北京100080

出　　处：《免疫学杂志》2007年第1期103-106,共4页Immunological Journal

基　　金：中国科学院引进海外杰出人才百人计划(2003-83);国家杰出青年基金(30425026);中国博士后基金(30020040300);中国科学院王宽诚博士后科研奖励基金(2004)资助

摘　　要：γ型干扰素在适应性免疫应答中起重要作用。在MHC-Ⅱ类分子限制性自身免疫病中,T细胞反应主要以1型辅助性T细胞(Th1)为主,并伴有IFN-γ水平增高,而剔除小鼠胸腺来源的CD4+CD25+调节性T细胞则导致自身免疫病的发生,有研究认为调节性T细胞在诱导免疫耐受产生的过程中起关键性作用。IFN-γ及其受体缺陷小鼠的CD4+CD25+调节性T细胞的免疫抑制能力明显受损,这表明IFN-γ及其受体在CD4+CD25+调节性T细胞免疫调节作用中以及在自身免疫病发生中可能发挥重要而复杂的免疫调节作用。本文仅就IFN-γ与调节性T细胞及自身免疫病发病三者之间关系的研究进展进行简要综述。Interferon-gamma plays an important role in the adaptive immtmity. T-cell responses in MHC-class- Ⅱ restricted autoimmune diseases appear to be Thl type predominant responses with the presence of high levels of IFN-γ. However, depletion of thymus-derived CD4^＋ CD25^＋ regulatory T cells in murine models results in the spontaneous development of autoimmune diseases, which suggesting that regulatory T cells are now beheved to play key role in inducing immune tolerance. The suppressive activity of CD4 ^＋ CD25^＋ regulatory T cell is much significantly impaired in IFN-γ- or IFN-γ receptor-deficient mice, which indicating that IFN-γ and its receptor play complex role in immunoregulatory response of CD4^＋ CD25^＋ T cells as well as in the control of autoimmune diseases. Tiffs review focused on the role of IFN-γ in the process of autoirmnuno diseases, the role of CD4^＋ CD25^＋ regulatory T cells in the pathogenesis of autoimmuaity, and the relationship among these three aspects.

关 键 词：调节性T细胞 自身免疫病 适应性免疫 γ型干扰素 

分 类 号：R392.11[医药卫生—免疫学]