Notch配体在诱导淋巴细胞分化中的不同作用  

Different roles of Notch ligands in inducing the differentiation of lymphocytes

作　　者：于哲[1] 邢飞跃[1] 曾耀英[1] 

机构地区：[1]暨南大学教育部组织移植与免疫重点实验室,广州510632

出　　处：《免疫学杂志》2007年第1期107-109,111,共4页Immunological Journal

基　　金：国家自然科学基金项目(30471635);广东省自然科学基金项目(04010451;5006033);暨南大学引进优秀人才科研启动基金项目(51204058)资助

摘　　要：脊椎动物Notch配体为一组单次跨膜蛋白,包括Delta1,Delta3,Delta4,Jagged1和Jagged2,它们与Notch受体结合激活Notch信号通路,决定细胞分化的命运。这些Notch配体具有不同的生物学特性,在诱导造血干/祖细胞和胸腺细胞向T、B和NK细胞分化中起着不同作用,可能为免疫性疾病的治疗提供新的药物靶点。Notch ligands in vertebrate, including Delta1, Delta3, Delta4, Jagged1, and Jagged2, belong to a single transmembrane protein. They bind to the related Notch receptors to decide the fate of cell differentiation. These ligands have different biological properties, which play different parts in inducing hematopoietic stem cells, hematopoietic progenitor cells, and thymocytes to develop into T cells, B cells, and NK cells. They, therefore, may offer a novel drug target for treating immunological diseases.

关 键 词：Delta1 Delta4 JAGGED1 Jagged2 淋巴细胞 分化 

分 类 号：R392[医药卫生—免疫学]