左旋聚乳酸/多壁碳纳米管/羟基磷灰石电纺丝纳米纤维的形态及生物降解性能  

Morphology and in Vitro Degradation Studies of Electrospun PLLA/MWNTs/HA Hybrid Nanofiber Scaffolds

作　　者：赵敏丽[1] 隋刚[1] 杨小平[1] 邓旭亮[2] 胡晓阳[2] 

机构地区：[1]北京化工大学北京市新型高分子材料制备与加工重点实验室,北京100029 [2]北京大学口腔医学院,北京100081

出　　处：《高分子材料科学与工程》2007年第1期112-116,共5页Polymer Materials Science & Engineering

基　　金：国家863项目(2004AA302G50);国家自然科学基金资助项目(30471907)

摘　　要：采用静电纺丝法制备了左旋聚乳酸/多壁碳纳米管/羟基磷灰石(PLLA/MW NT s/HA)杂化纳米纤维无纺毡,分析了MW NT s的加入对杂化纤维形态结构的影响,以及不同工艺条件下纤维的直径分布,并研究了纤维无纺毡在磷酸盐缓冲溶液(pH 7.4,37℃)中的体外降解过程。结果表明:MW NT s的加入使PLLA/HA纤维直径略有减小;PLLA/MW NT s/HA杂化纤维体系降解液的pH值下降到一定程度后,在降解后期呈缓慢上升趋势;碱性MW NT s/HA的加入抑制了PLLA降解过程中的自催化作用,减缓了PLLA的降解速度。Novel Poly（1-1actic acid） （PLLA）/Multi-walled carbon nanotubes （MWNTs）/ hydroxyapatite （HA） nanofibrous scaffolds with high porosity and well-controlled pore architectures were prepared using electrospinning techniques. The electrospun process of fibers and surface degradation behaviors of fiber mats were studied. The results show that the scaffolds have a perfect micro-cellular structure ; The surface of hybrid fibers is much coarse clue to the introduction of HA nano-particles; The viscosity- average molecular weight of scaffolds drops in a linear manner with degradation time, while the mass loss and water uptake of the scaffolds are gradual increased, the pH of hybrid system is decreased gradually first and then increased at the end of degradation time; The alkaline MWNTs/HA nano-particles inhibit the self-catalysis ot PLLA during the degradation times and slow down the degradation rates of PLLA nanofibers.

关 键 词：聚乳酸 羟基磷灰石 碳纳米管 电纺丝 体外降解 

分 类 号：TB383[一般工业技术—材料科学与工程]