磁性壳聚糖-5-氟尿嘧啶纳米粒的制备及体外释药性能  

Preparation and in Vitro Release of Magnetic Citosan-5-Fluorouracil Nanoparticles

作　　者：李和平[1] 肖华伍[2] 肖子丹[1] 阮建明[3] 

机构地区：[1]长沙理工大学化学与环境工程学院,湖南长沙410076 [2]中南大学湘雅医院,湖南长沙410083 [3]中南大学粉末冶金国家重点实验室,湖南长沙410083

出　　处：《高分子材料科学与工程》2007年第1期189-191,195,共4页Polymer Materials Science & Engineering

基　　金：国家863项目(2001AA218011);湖南省自然科学基金(06JJ20038);长沙理工大学科研基金(04xxrc031);湖南省青年骨干教师培养基金

摘　　要：采用交联-聚合法在超声波的作用下,制备了磁性壳聚糖-5-氟尿嘧啶纳米粒(M CN-Fu)。透射电子显微镜(TEM)和红外光谱(IR)等分析结果表明,M CN-Fu粒子外形规整,分散性好,粒径主要在50 nm^60 nm之间。紫外-可见光谱分析结果表明,M CN-Fu的载药量为21.3%,在磷酸盐缓冲溶液(pH=7.2)中,30 h的累积释药率为67.6%,具有良好缓释性能,并具有良好磁响应性能。In order to prepare the targeting drug-loaded system, magnetic chitosan-5-Fu nanoparticles （MCN-Fu） were prepared by using 5-Fu as a model drug, Fe3O4nanoparticles as the core and glutaraldehyde as cross-linking agent under ultrasonic treatment. TEM images show that MCN-Fu are spherical shape with diameters ranged from 50 nm- 60 nm. The IR results indicate there is a strong molecular interaction between 5-Fu and chitosan. The drug content, in vitro release and magnetic properties of MCN-Fu were investigated by UV-vis spectrum. The results indicate that the drug content is 21.3%, and accumulative release percentage in phosphate buffer （pH=7.2） solution is 67.6% in 30 h , the drug release rate is found decreased and they can in some degree reduce initial burst. MCN-Fu have good magnetic properties and target effect.

关 键 词：磁性 壳聚糖 氟尿嘧啶 纳米粒 药物缓释剂 

分 类 号：TB383[一般工业技术—材料科学与工程]