骨组织工程用n-HA/PA66多孔贯通支架的制备及表征  

Fabrication and Characterization of n-HA/PA66 Composite Scaffold for Bone Tissue Engineering

作　　者：王华楠[1] 李玉宝[1] 左奕[1] 程琳[1] 王园园[1] 石浦江[1] 

机构地区：[1]四川大学纳米生物材料研究中心,分析测试中心,四川成都610064

出　　处：《高分子材料科学与工程》2007年第1期230-233,共4页Polymer Materials Science & Engineering

基　　金：国家973项目(中荷战略科学联盟计划项目;2004CB720604)资助

摘　　要：为了解决生物降解性骨组织工程支架难以与人体骨力学强度相匹配的缺点,选用具有良好生物相容性和力学性能的纳米羟基磷灰石/聚酰胺66(n-HA/PA 66)复合材料作为基材,通过相转移法和粒子沥滤法相结合的工艺制备了一种骨组织工程用多孔贯通支架。用扫描电子显微镜(SEM)、X射线衍射(XRD)、红外光谱(IR)和万能力学试验机等手段对多孔支架的理化性能进行表征。结果显示,n-HA/PA 66多孔支架具有较为理想的孔隙结构和贯通性,且其压缩强度与人体松质骨相当,可满足骨组织工程支架的基本要求。因其具有非生物降解特性,故可为骨组织的再生提供持续稳定的力学支撑。In order to solve the problem that the mechanical strength of most biodegradable tissue-engineered scaffolds cannot match with that of cancellous bone, nano-hydroxyapatite and polyamide66 composite was used to fabricate porous scaffold. A processing method of phase inversion in combination with particle leaching was introduced to prepare n-HA/PA66 porous scaffolds with good biocompatibility and mechanical strength. The morphologies and properties of the scaffolds were characterized by scanning electronic microscope （SEM）, X-ray diffraction （XRD）, infrared spectroscopy （IR） and mechanical testing machine. The results indicate that n-HA/ PA66 composite scaffold possesses ideal pore size （100 μm-500 μm） and interconnectivity suitable for new bone ingrowth. Moreover, the scaffold exhibites good mechanical strength （2 MPa -37 MPa） that is similar to the cancellous bone （2 MPa-10 MPa）. Due to its non-biodegradability, this composite scaffold is able to provide a long-term stable support for the regeneration of new bone.

关 键 词：骨组织工程 支架 纳米羟基磷灰石 聚酰胺 复合材料 孔隙率 制备工艺 

分 类 号：TB39[一般工业技术—材料科学与工程]