^11C-胆碱PET／CT显像在前列腺癌诊断中的应用价值  

Application of ^11C-choline PET/CT imaging in the diagnosis of prostate cancer

作　　者：王慕文[1] 金讯波[1] 赵勇[1] 蒋绍博[1] 李昕[2] 夏庆华[1] 熊晖[1] 孙鹏[1] 陈修德[1] 王正[1] 

机构地区：[1]山东大学山东省立医院泌尿微创中心,济南250021 [2]山东大学山东省立医院PET／CT中心,济南250021

出　　处：《中华泌尿外科杂志》2007年第1期53-56,共4页Chinese Journal of Urology

基　　金：山东省科技发展计划基金资助项目（2004GG2202140）

摘　　要：目的探讨^11C-胆碱PET／CT显像在前列腺癌诊断中的临床价值。方法42例PSA升高的可疑前列腺癌患者为研究组，5例浸润性膀胱癌患者为阴性对照组，静脉注射7．4MBq／kg^11C-胆碱5min后行仰卧位盆腔PET／CT显像，可疑转移者行全身显像。测量最高标准化摄取值（SUVmax）并计算前列腺病灶与肌肉组织SUVmax的比值T／B。结果经病理证实为前列腺癌者22例，良性前列腺增生（BPH）者25例（含对照组），两者的T／B值分别为4．32±1．35和1．68±1．23，差异有统计学意义（P〈0．01）。^11C-胆碱PET／CT显像诊断前列腺癌的敏感性为81．8％（18／22），特异性为84．0％（21／25）。PET／CT显示9例前列腺癌患者伴骨和（或）淋巴结及肺转移。22例前列腺癌者SUVmax与PSA值、Gleason评分值无相关性（P〉0．05）。结论^11C-胆碱PET／CT显像对前列腺癌的诊断有重要价值。Objective To evaluate the clinical value of ^11C-choline PET/CT imaging in the diagnosis of prostate cancer. Methods This series included 42 suspected cases of prostatic cancer with increased PSA and 5 control subieets with bladder cancer. PET/CT imaging was performed 5min after injection of the tracer ^11C-choline,7.4 MBq/kg in supine position, covering the pelvis, and the whole body when necessary. ^11C-choline uptake was analyzed semiquantitatively by using the maximum standardized uptake values （SUVmax） and tumor-to background （T/B） ratio for prostatic lesions. Results Twenty-two cases of prostate cancer and 25 cases of benign prostate hyperplasia （BPH） were proven histopathologically. The differences in T/B ratios between prostate cancer and BPH cases were statistiealy significant （P〈0.01）. ^11C-choline PET/CT imaging analysis had sensitivity of 81.8% and specificity of 84.0% for diagnosing prostate cancer. All 9 cases of known bone and lymph node or lung metastases were recognized by ^11C-choline PET/CT. There was no statistically significant linear correlation between SUVmax and PSA or Gleason score in 22 cases of prostate cancer（P〈0.05）. Conclusions ^11C-choline PET/CT is a promising new tool for the diagnosis of prostate cancer.

关 键 词：前列腺肿瘤 胆碱 正电子 体层摄影术 诊断 

分 类 号：R686[医药卫生—骨科学]