β-淀粉样斑块显像剂的研究  

Advances in Imaging Agents for β-Amyloid Plaques

作　　者：陈祥纪[1] 

机构地区：[1]北京师范大学化学学院放射性药物教育部重点实验室,北京100875

出　　处：《化学进展》2007年第1期123-129,共7页Progress in Chemistry

基　　金：国家自然科学基金项目资助(No.20471011)

摘　　要：阿尔茨海默病(AD)是一种脑神经退变性疾病。在AD发病机理方面,脑中β-淀粉样斑块的形成是一个主要因素,β-淀粉样斑块显像剂对于AD的早期诊断具有重要的临床意义。结合本实验室工作,本文介绍了β-淀粉样斑块显像剂的发展过程和目前国内外的最新进展,并对β-淀粉样斑块显像剂的未来发展方向作了展望。Alzheimer＇s disease （AD） is a kind of degenerative neurodisease. The formation of β-amyloid plaques in brain is one of the main factors in developing of AD. Imaging agents for β-amyloid plaques are of great significance to early diagnosis of AD. The recent advances in imaging agents for β-amyloid plaques domestic and abroad as well as work in my laboratory are reviewed in this paper. The trend for developing β-amyloid plaques imaging agents is also discussed.

关 键 词：阿尔茨海默病 β-淀粉样斑块 显像剂 

分 类 号：O615.4[理学—无机化学] O628[理学—化学]