微流控芯片系统中固液双相分离富集技术  

Separation and Concentration Methodologies by Solid-Liquid Dual Phase Interaction on Micro-Fluidic Chip System

作　　者：徐溢[1] 张剑[1] 徐平洲[1] 卢倩[1] 曾雪[1] 温志渝[2] 

机构地区：[1]重庆大学化学化工学院,重庆400044 [2]重庆大学微系统研究中心,重庆400044

出　　处：《化学进展》2007年第1期186-192,共7页Progress in Chemistry

基　　金：国家自然科学基金项目(No.90307015;20007005);重庆市重点自然科学基金项目(No.20675089)资助

摘　　要：发展微流控芯片系统中的分离富集技术,是微全分析系统向集成化、自动化和便携化发展必须突破的瓶颈之一,正逐步成为微全分析系统研究和应用领域的前沿和热点。本文针对应用广泛的固液双相分离富集技术,详细介绍了过滤式、膜分离式、固相萃取式等不同分离富集操作模式在微流控芯片系统中的应用,对每一种操作模式的特点、研究现状、存在的问题和发展趋势进行了综述。With the developing of miniaturized total analytical system （μTAS）, much more attention is paid to integration, automation and portability of analytical systems. However, the sample pretreatment methodology integrated on micro-fluidic chip became a bottleneck for μ-TAS, and was focused by researchers in this field. The important sample pretreatment technology based on solid-liquid dual phase interaction is introduced in this paper. Different operational modes, such as filtration, membrane separation and solid-phase extraction, are discussed in detail. Furthermore, the characteristics, current developments, existing problems and trends of these operational modes are reviewed.

关 键 词：微流控芯片系统 固液双相分离富集 过滤 膜分离 固相萃取 

分 类 号：O658[理学—分析化学] Q503[理学—化学]