睡眠呼吸暂停综合征认知功能障碍  

Event-related potential and clinical study on cognitive dysfunction of sleep apnea syndrome

作　　者：朱静[1] 于逢春[1] 高玉红[1] 王小轶[2] 张晓君[1] 

机构地区：[1]首都医科大学附属北京同仁医院神经内科,北京100730 [2]首都医科大学附属北京同仁医院耳鼻咽喉头颈外科,北京100730

出　　处：《中国耳鼻咽喉头颈外科》2006年第12期839-842,共4页Chinese Archives of Otolaryngology-Head and Neck Surgery

摘　　要：目的了解睡眠呼吸暂停综合征(sleep apnea syndrome,SAS)患者认知功能损害及各种检测方法的敏感性。方法应用病例对照研究方法,对24例SAS患者和22例健康人进行二音偏倚刺激序列听觉事件相关电位P300、三音听觉事件相关电位P300及简易智能精神状态量表(mini-mentalstatusestimate,MMSE)检测,比较两组间的P300电位潜伏期和MMSE结果以及不同检测方法之间的异常率。结果研究组2t-P300为(341±14.5)毫秒,(342±13.8)毫秒;对照组2t-P300为(317±14.7)毫秒,(318±12.8)毫秒;研究组r-dT1为(327±13.0)毫秒,(326±14.9)毫秒;对照组r-dT1为(309±11.1)毫秒,(309±12.0)毫秒;研究组r-dT2为(325±14.9)毫秒,(326±11.1)毫秒;对照组r-dT2为(306±9.7)毫秒,(305±11.7)毫秒。研究组所有序列诱发的P300潜伏期均较对照组延长,统计学差异有显著性。三音与二音P300异常率无明显差别。所有受试者MMSE得分均在正常范围(27分以上),但研究组得分低于对照组,两组间差异有显著性。结论SAS患者认知功能较正常人下降。事件相关电位比MMSE较早地发现认知功能损害。本组患者中三音听觉P300与传统二音听觉P300敏感度无明显差异。OBJECTIVE To explore cognitive dysfunction of sleep apnea syndrome （SAS） and compare the sensitivity of different measuring methods. METHODS Odd ball auditory P300 （2t- P300）, threetone paradigm auditory P300 （3t-P300） and minimental status estimate （MMSE） were performed on 24 patients with SAS and 22 healthy subjects. Results of two groups were compared. RESULTS 2t- P300 of study group：（33,1±14.5）ms, （342±13.8）ms; 2t- P300 of normal group：（317±14.7）ms, （318±12.8）ms; r-dT1 of study group：（327±13.0）ms,（326 ±_ 14.9）ms; r-dT1 of normal group： （309±11.1）ms,（309±12.0）ms; r-dT2 of study group：（325±14.9）ms,（326±11.1 ）ms; r-dT2 of normal group：（306±9.7）ms, （305±11.7）ms.Latency of P300 evoked by odd-ball and 3-tone paradigm were both statistically prolonged in SAS patients than those of normal controls. SAS patients had statistically lower MMSE scores than that of normal group but all of them were above 27. On the other hand, statistical difference of abnormal rate between 3-tone P300 and odd-ball P300 was not found in SAS patients group. CONCLUSION Cognitive function impairment was found in SAS patients both by P300 and MMSE. While P300 might be more sensitive than MMSE in detecting it, different paradigm of auditory P300 did not show difference in sensitivity.

关 键 词：睡眠呼吸暂停综合征 认知障碍 事件相关电位 P300 

分 类 号：R766[医药卫生—耳鼻咽喉科]