中药冲洗对鼻黏膜纤毛超微结构的影响  

Role of irrigation at nasal cavity with Chinese herbal liquid on the ultrastructure of nasal mucocilia after functional endoscopic sinus surgery

作　　者：李学昌[1] 王金磊[1] 张玉莉[1] 董文汇[1] 韩在文[1] 

机构地区：[1]潍坊市人民医院耳鼻咽喉科,山东潍坊261041

出　　处：《山东大学耳鼻喉眼学报》2006年第6期522-524,共3页Journal of Otolaryngology and Ophthalmology of Shandong University

摘　　要：目的:观察慢性鼻-鼻窦炎患者在鼻内窥镜术后应用鼻窦炎口服液冲洗鼻腔,对鼻黏膜纤毛超微结构的影响。方法:对30例接受FESS的慢性鼻-鼻窦炎患者,术后分A、B、C三组用不同方法处理,对各组患者分别于术前、术后3个月取上颌窦口周围黏膜进行电镜观察,另取2例作为健康对照。结果:术前各组黏膜上皮纤毛脱落,排列紊乱,间质水肿,可见中性粒细胞及杯状细胞。线粒体减少,明显肿胀,出现空泡。纤毛融合,微管结构异常;术后A、B组纤毛排列较整齐,粗细亦均匀,方向较一致,且纤毛丰富、密集,“9+2”微管结构清晰,线粒体狭长致密,与健康对照组结构无明显差异;术后C组可见纤毛数量明显增多,排列尚整齐,方向欠统一,并可见大量短纤毛,线粒体仍肿胀,仍可见病理性改变。结论:鼻内镜手术后应用鼻窦炎口服液冲洗能促进鼻黏膜纤毛结构的恢复。Objective： To obseive the influence of irrigation at nasal cavity with Bidouyan oral liquid on the ultrastructure of nasal mucocilia after endoscopic sinus surgery（ESS） in patients with chronic rhinosinusitis. Methods： Thirty patients with chronic rhinosinusitis were dealt with endoscopic sinus surgery and then divided into three groups at random. Group A： 500 ml physiologic saline adding 20 ml Bidouyan oral liquid was applied for nasal cavity irrigation for 3 days to 3 months after ESS, twice each week. Group B： 500 ml physiologic saline adding 80 000 U gentamycin and 5 mg dexamethasone solution was applied for nasal cavity irrigation after ESS, twice each week. Group C： 500 ml physiologic saline alone was applied for nasal cavity irrigation after surgery. All the patients accepted saccharin test before surgery and three months after surgery, and 2 healthy cases were observed as controls. Results： The mucosa was examined with electron microscope before surgery and three months after surgery. After surgery, the cilia arranged in order and densely, and the structure of ＂9 ＋ 2＂ canaliculus was normal. Condusion： Irrigation at nasal cavity with Bidouyan oral liquid after surgery can accelerate the recovering of nasal mucosa.

关 键 词：外科手术 内窥镜 鼻窦炎 鼻黏膜 鼻腔 

分 类 号：R765.9[医药卫生—耳鼻咽喉科]