鸦胆子与补骨脂对大鼠卡氏肺孢子虫肺炎疗效的电镜观察  

Electron Microscopical Observation on Rats with Pneumocystis carinii Pneumonia Treated with Brucea javanica and Fructus Psoraleae

作　　者：任一鑫[1] 秦元华[1] 郑莉莉[1] 戴晓冬[1] 陶林[1] 陈玉凤[1] 崔昱[1] 

机构地区：[1]大连医科大学寄生虫学教研室,大连116023

出　　处：《中国寄生虫学与寄生虫病杂志》2006年第6期473-475,共3页Chinese Journal of Parasitology and Parasitic Diseases

基　　金：辽宁省教育厅科学研究计划资助(2004D103)~~

摘　　要：用鸦胆子和补骨脂合剂2ml(鸦胆子0.12mg+补骨脂1.0mg)分别治疗经地塞米松皮下注射诱导的卡氏肺孢子虫肺炎(Pneumocystiscariniipneumonia,PCP)的SD大鼠7天和14天,同时设阳性对照组和正常对照组。分别于治疗后剖杀各组大鼠,取肺组织制成切片。透射电镜下观察到治疗组大鼠受损肺组织病变减轻,肺间质、Ⅰ型和Ⅱ型肺泡上皮细胞形态结构修复。说明鸦胆子和补骨脂合剂对卡氏肺孢子虫肺炎病鼠有一定的疗效。Rats with Pneumocystis carinii pneumonia （PCP） were estabhshed by hypodermic injection of dexamethasone and treated by brucea javanica combined with fructus psoraleae 2 ml （Brucea javanica 0.12 mg and fructus psoraleae 1.0 mg） per rat per day for 7 days or 14 days. The effect of cyst-killing and the pathological change were observed under transmission electron microscope. Lung damage was alleviated or repaired, and a significant reduction of cysts was shown in the treatment group. The results show that a combination of Brucea javanica and fructus psoraleae played a significant restraining and killing effect on cysts, and helped repair the impairment of pneumonia.

关 键 词：卡氏肺孢子虫肺炎 大鼠 鸦胆子 补骨脂 疗效 透射电镜 

分 类 号：R531.9[医药卫生—内科学]