黄白液对复发性生殖器疱疹患者皮损中人β防御素-2mRNA表达的影响  

Effect of Huangbai Liquid on Expression of Human β-defensin-2mRNA in Skin Lesions of Patients with Recurrent Genital Herpes

作　　者：任小丽[1] 陈晋广[1] 

机构地区：[1]浙江省台州市立医院皮肤科,浙江318000

出　　处：《中国中西医结合杂志》2006年第12期1119-1121,共3页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的探讨复发性生殖器疱疹(recurrent genital herpes,RGH)患者皮损中人β防御素-2(humanβ-defensin-2,HBD-2)的表达情况及黄白液对其影响。方法27例RGH患者随机分为黄白液组14例,泛昔洛韦组13例,于治疗前后检测HBD-2的表达情况,并与10名健康人进行比较。结果健康人和RGH患者皮损均可检测到HBD-2的表达,治疗后患者HBD-2表达,黄白液组高于泛昔洛韦组。结论黄白液适用于RGH治疗,可保持患者局部HBD-2的较高浓度表达,以改善患者的免疫功能。Objective To investigate the expression of human β-defensin-2 （HBD-2） mRNA in skin lesions of patients with recurrent genital herpes （RGH） and the effect of Huangbai Liquid （HL） on it. Methods Twenty-seven patients were randomly assigned to 2 groups, the HL group （ n = 14） treated with HL and the famciclovir group （n = 13） with famciclovir. HBD-2 expression of patients were detected before and after the treatment and compared with that of 10 healthy subjects. Results HBD-2 expression was found in the skin lesions of both the healthy persons and the RGH patients before treatment. It is higher significantly in the HL group than in the famciclovir group after treatment. Conclusion HL was suitable for treatment of RGH since it could improve immune function of RGH patients and keep a rather higher concentration of HBD-2 expression in local skin lesions.

关 键 词：复发性生殖器疱疹 黄白液 人Β防御素-2 

分 类 号：R275[医药卫生—中医皮科]