芩荑合剂治疗实验性哮喘动物模型气道变应性炎症的机理研究  

Research on the Mechanism of Qinyiheji Treating Allergic Airway Inflammation of the Laboraty Asthma Animal Model

作　　者：杨继兵[1] 朱永忠[2] 刘隆棣[1] 汪悦[1] 方泰惠[1] 

机构地区：[1]南京中医药大学,江苏南京210029 [2]南京市胸科医院,江苏南京210000

出　　处：《中华中医药学刊》2007年第1期90-92,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：江苏省教委基金项目(99KJB360004)

摘　　要：目的:以芩荑合剂为基础,制成超声雾化液,通过实验观察探讨其作用机理。方法:观察该方对卵白蛋白致敏哮喘动物模型支气管肺泡灌洗液(BALF)中Eo、IL-3、IL-5、GM-CSF、SIL-2R、NO的影响。结果:实验发现:芩荑合剂雾化液能显著降低炎性指标(Eo、IL-3、IL-5、GM-CSF、SIL-2R、NO)。病理切片证实治疗组支气管肺组织中E0等炎症细胞浸润减少。结论:芩荑合剂具有解痉、平喘、抗炎、祛痰等作用。其作用机理可能与拮抗了气道的E0等炎症细胞浸润、活化及相关细胞因子、炎性介质释放有关。Objective：. Based on Qinyiheji ,we suceessfugy produce the supersonic inhaler and probe the mechinism through the laboratry observation. Methods：To observe the effects of Qinyiheji supersonic inhaler on ovalbumin asthma guiea pig model with bronchalveolar avage fluid （BALF） Eo ,IL-3 ,IL-5 ,GM-CSF,SIL-2R,NO as index. Result：The reserch showed that Qinyjheji supersonic inhaler can decrease the content of Eosinophis in BALF, suepmomal IL-3 ,IL-5 ,GM-CSF,SIL-2R,NO（P 〈 0.05 ） significantly. Pathologic section proved that infiltration of E0 ,eet inflammatory cells in lung and bronchus have decreased significantly in curing group. Conclusion： Qinyjheji supersonic inhaler has the effects of spasmolysis, anti-asthma, anti-inflammatlon, epispectum, its action mechnism might concern about resisting the airway infiltration and activation of Eo,ect inflammatory cells,and be related to release of cell factors and inflammatory medicator.

关 键 词：支气管哮喘 芩荑合剂雾化液 气道变应性炎症 实验研究 

分 类 号：R285.5[医药卫生—中药学]