白细胞介素-10在慢性阻塞性肺病检测中的意义  

Clinical Significance of IL-10 in Patients with COPD

作　　者：王喜英[1] 吴波[1] 张愔[1] 

机构地区：[1]郑州大学第一附属医院检验科,郑州市450052

出　　处：《医药论坛杂志》2006年第24期19-20,共2页Journal of Medical Forum

摘　　要：目的探讨白细胞介素-10(IL-10)、Ig、C3、C4与慢性阻塞性肺病(COPD)的关系及临床意义。方法选择20例COPD患者为观察组,20例健康老年人作正常对照。①采用双抗体夹心ELISA(生物素扩大)法,测定各例血清IL-10浓度。②采用散射比浊法测定各例血清Ig、C3、C4含量。结果20例健康老年人血清IL-10的含量为(11.49±4.24)Pg/mL、IgG(11.3±2.21)g/L、IgA(1.9±0.7)g/L、IgM(1.4±0.36)g/L、C3(1.2±0.22)g/L、C4(0.3±0.09)g/L。20例COPD患者血清IL-10含量为(63.18±48.35)Pg/m l、IgG(12.5±3.56)g/L、IgA(3.1±1.32)g/L、IgM(2.6±0.94)g/L、C3(1.6±0.5)g/L、C4(0.5±0.14)g/L。结论COPD患者的IL-10、IgA、IgM、C3、C4、与健康老年人相比差异有显著性(P<0.001),提示IL-10参与了COPD的发病机制和体液免疫调节,血清IL-10检测是COPD病情监测和疗效判断的较好指标。Objective To investigate the relationship between the serum level of intedeukin -10 （IL- 10） ,Ig,C3,C4 and chronic obstructive pulmonary disease（COPD）. Methods Choose 20 patients with COPD while 20 healthy elders were controls. ① The serum concentrations of IL - 10 were assayed by enzyme linked immunosorbent assay （ELISA）. ② The serum concentrations of Ig, C3,C4 were assayed by nephelometry. Results The mean concentration of the eases was（63.18 ± 48. 35） Pg/ml,IgG（ 11.3 ±2. 21 ） g/L,IgA （ 1.9 ±0. 7）g/L, IgM（ 1.4 ±0. 36）g/L, C3 （ 1.2 ±0. 22） g/L, C4 （0. 3 ± 0. 09 ） g/L, while the controls was （ 11.49 ± 4. 24 ） Pg/ml, IgG （ 12. 5 ± 3.56 ） g/L, IgA （3.1 ±1.32）g/L,IgM（2. 6±0. 94）g/L,C3 （1.6 ±0. 5）g/L,C4（0. 5 ±0. 14） g/L. Conclusion The serum level of IL -10, IgA, IgM, C3, C4 in patients was different significantly from that of the controis （P 〈 0. 001） ,suggesting that IL- 10 was involved in the pathological development of COPD, and the serum level of IL- 10 was an appropriate index to evaluate COPD ,and the effect of treatment.

关 键 词：白细胞介素-10 慢性阻塞性肺病 免疫球蛋白 C3 CA 

分 类 号：R563[医药卫生—呼吸系统]