联合用药对子痫前期的预防作用  

Role of Combination Treatment on Prevention of Preeclampsia

作　　者：王宝珍[1] 张颖[2] 郭晓凌[2] 王军[2] 

机构地区：[1]辉县市人民医院妇产科,辉县市453600 [2]郑州大学第三附属医院,郑州市450052

出　　处：《医药论坛杂志》2006年第24期40-42,共3页Journal of Medical Forum

摘　　要：目的探讨联合应用小剂量阿司匹林、维生素E、乐力钙在预防子痫前期发病中的作用。方法选择子痫前期高危孕妇46例,将其随机分为治疗组及对照组各23例,治疗组每日给予阿司匹林75mg、维生素E100mg、乐力钙2.0g口服,至分娩。对照组按常规处理。结果无论是轻度或重度子痫前期,治疗组的发病率(13.0%)均显著低于对照组(39.1%)(P<0.05);治疗组早产率、死胎率及新生儿窒息发生率均显著低于对照组(P<0.05),而产后出血及胎盘早剥发生率在两组间无显著差异(P>0.05)。结论联合应用小剂量阿司匹林、维生素E、乐力钙对子痫前期的发生有着重要的预防价值。Objective To compare a combination treatment of low - dose aspirin, vitamin E and osteoform in women at high risk of preeclampsia. Methods 46 eases of preeclampsia high - risk women were classified into two groups randomly, treatment group 23 cases and control group 23 cases. Treatment group was treated with aspirin （75mg/d）, vitamin E （100mg/d） and osteoform （2. 0g/d） throughout their pregnancies. Results The incidence （ 13. eclampsia in treatment group was markedly lower than that（ 39. 1% ） in 0% ） of mild or severe precontrol group（ P 〈 0. 05 ） ; The incidence of premature delivery, fetal death and asphyxia of newborn in treatment group was markedly lower than that in control group （ P 〈 0. 05 ） ; We found no differences between treatment group and control group in numbers of postpartum hemorrhage and placental abruption （ P 〉 0. 05 ）. Conclusion Our study gives supports to the notion that combination treatment of low - dose aspirin, vitamin E and osteoform is beneficial in women at high risk of preeclampsia.

关 键 词：子痫前期 阿司匹林 维生素E 乐力钙 

分 类 号：R714.24[医药卫生—妇产科学]