黄芪注射液联合贝复济外敷治疗糖尿病足部溃疡88例疗效观察  

Treatment of Ulcer of Diabetic Foot by Huangqi Injection Combined with External Compress of Beifuji: A Clinical Observation of 88 Cases

作　　者：周倩[1] 肖正华[1] 陈定宇[1] 黄春苓[1] 

机构地区：[1]广州医学院附属广州市第一人民医院,广东广州510180

出　　处：《新中医》2007年第1期66-67,共2页New Chinese Medicine

基　　金：广东省中医药局科研课题(编号:400008)

摘　　要：目的:观察黄芪注射液联合贝复济外敷治疗糖尿病足部溃疡的临床疗效。方法:将88例患者随机分为4组,在内科综合治疗的基础上,溃疡局部分别给予外用药治疗。观察足部溃疡肉芽组织开始出现时间(GT)、溃疡愈合时间(HT)及截肢率、死亡率的变化。结果:贝复济组相同病情程度的患者其相应的GT和产HT均稍长于黄芪组(P>0．05);联合组的GT较黄芪组及贝复济组为短(P>0．05),联合组HT显著短于黄芪组和贝复济组(P<0．05)。与对照组比较,黄芪组、贝复济组、联合组GT及HT均显著缩短(P<0．05,P< 0．01),死亡率差异无显著性意义(P>0．05),但3组截肢率、死亡率均显著低于对照组(P<0．01,P< 0．05),联合组的截肢率低于黄芪组、贝复济组(P<0．05)。结论:黄芪注射液联合贝复济外敷治疗Ⅰ-Ⅱ级糖尿病足部溃疡能缩短溃疡愈合时间,提高治愈率,降低截肢率。Objective:To observe the clinical effect of Huangqi injection (HI,黄芪注射液) combined with external compress of Beifuji (贝复济) for ulcer of diabetic foot. Methods: 88 cases were allocated to 4 groups randomly and were treated by comprehensive internal medicine and external compress on topical ulcerous part, the changes of granulation lime (GT) of fool ulcer, healing time (HT), ampulation rate and mortality were observed. Results: The correlative GH and HT of identical degree of Beifuji group was slightly longer than Radix Astragali group ( P > 0. 05); the GT of combined treatment group was shorter than that of Radix Astragali group and Beifuji group ( P > 0. 05); the HT of combined treatment group was markedly shorter than that of Radix Astragali group and Beifuji group (P < 0.05). The comparison with control group, the GT and HT of Radix Astragali group, Beifuji group and combined treatment group were markedly shorter (P < 0. 05, P < 0. 01). The comparison of mortality among 4 groups showed no marked difference (P > 0. 05), but the amputation rate and mortality of 3 groups were markedly lower than that of Radix Astragali group and Beifuji group (P < 0. 05). Conclusion: HI combined with external compress can shorten the HT inⅠ-Ⅱgrade of ulcer of diabetic foot, increase the cured rate and lower the amputation rate.

关 键 词：糖尿病足 黄芪注射液 贝复济 投药 局部 

分 类 号：R259.872[医药卫生—中西医结合]