金黄色葡萄球菌耐药性监测  

Surveillance of Antimicrobial Resistance in Staphylococcus Aureus

作　　者：马筱玲[1] 孙光明[1] 戴媛媛[1] 陈多炎[1] 鲁怀伟[1] 

机构地区：[1]安徽省立医院,合肥230001

出　　处：《临床输血与检验》2007年第1期18-20,共3页Journal of Clinical Transfusion and Laboratory Medicine

摘　　要：目的了解金黄色葡萄球菌耐药状况,为临床合理选用抗菌药物提供依据。方法采用VITEK32全自动微生物分析仪GPS药敏板,检测205株金黄色葡萄球菌对15种抗菌药物的敏感性。结果金葡菌对不同抗菌药物的耐药率依次为:青霉素G(95.1%)、氨苄西林(80.5%)、红霉素(75.6%)、克林霉素(48.8%)、头孢唑啉(42.4%)、庆大霉素(42.4%)、四环素(42.0%)、苯唑西林(42.0%)、左氧氟沙星(36.2%)、环丙沙星(35.2%)、甲氧苄啶/磺胺甲唑(25.9%)、氯霉素(21.7%)、利福平(5.3%)、呋喃妥因(2.0%)、万古霉素(0);205株金葡菌中共检出86株耐甲氧西林金黄色葡萄球菌(MR-SA),与甲氧西林敏感的金黄色葡萄球菌(MSSA)相比,除万古霉素、呋喃妥因、青霉素G外,MRSA对其他抗菌药物的耐药率显著高于MSSA(P<0.05),同时,MRSA对非β-内酰胺类抗菌药物的多重耐药率也显著高于MSSA。结论临床分离的金葡菌对多种抗菌药物的耐药率高,尤其是MRSA感染的多重耐药情况较严重,临床微生物实验室应加强对MRSA的监测。Objective To investigate the antiraierobial resistance of staphylococcus aureus and offer data for reasonable antimierobial agents in our hospital. Methods The antimicrobial sensitivity tests of 205 isolates of Staphylococcus aureus were tested by VITEK32 automatic microbial monitor GPS. Results The resistance rates to different antibiotic of 205 isolates of Staphylococcus aureus were Penicillin （9 5.1 % ）, Ampieillin （80.5 % ）, Erythromycin （7 5.6 % ）, Clindamicin （48. 8 % ）, Cefazolin （ 42. 4 % ）, Gentamicin （ 42.4 % ）, Tetracycline （ 42.0 % ）, Oxacillin （ 42.0 % ）, Levofloxacin （ 36. 2 % ）, Trimethoprim/sulfa （25.9 % ）, Chloramphenicol （21.7 %）, Rifampin （5.3% ）, Nitrofurantoin （2.0 % ） and Vaneomyein （0）., 86 strains of MRSA were detected from 205 isolates oLStaphyloeoecus aureus by MIC〉4μg/ml of Oxacillin with GPS. The resistantce rates of MRSA were higher than MSSA except for Vaneomycin,Nitrofurantoin and Penicillin （P〈0.05） and the multi-resistance rates of MRSA were also higher than MSSA. Conclusion Resistance rates of clinical isolates of staphylococcus aureus to most antibiotics were higher, especially multi-reslstant MRSA strains,we shoud strengthen the surveillance of MRSA in clinical microbiology laboratory.

关 键 词：金黄色葡萄球菌 耐药 甲氧西林 

分 类 号：R378.11[医药卫生—病原生物学] R969.3[医药卫生—基础医学]