华法林治疗中监测凝血酶原时间的临床应用  

The Clinical Application of Prothrombin Time While Taking Warfarin Orally

作　　者：杨桂斌[1] 张夏[1] 黄传荣[1] 黄明[1] 王建华[1] 

机构地区：[1]安徽省阜阳市人民医院检验科,236003

出　　处：《临床输血与检验》2007年第1期27-29,共3页Journal of Clinical Transfusion and Laboratory Medicine

摘　　要：目的探讨口服华法林抗凝治疗时凝血酶原时间(PT)-INR监测最佳间隔时间。方法对59例心脏瓣膜置换术后患者,应用ACL-200全自动血凝仪,测定PT、凝血酶原时间比值(PTR)、国际正常化比率(INR),记录患者监测PT间隔时间及抗凝期间的并发症。结果PT11.6～48s,PTR1.00～4.13,INR1.05～7.22;82.6%例次PT16.5～24s,PTR1.29～1.88,INR1.5～2.5;监测间隔3～138d,84.7%例次间隔11～70d。出现并发症为发生脑梗死3例,出血8例,2例出现皮肤瘙痒、皮疹。结论PT对口服华法林的监测具有很好的临床应用价值;以INR2.0±0.5为最佳抗凝标准,在患者术后出院INR调整稳定后,监测PT最佳间隔时间为30d。Objective Research on the clinical value of monitoring PT while taking warfarin orally for anticoagulation. Methods Making use of ACL-200 to dertermine PT,PTR,INR for the 59 cases after the operation of heart value prosthesis, Results PT differed from 11.6 to 48 seconds,PTR 1.00-4. 13,INR 1.05- 7.22,of 82.6% cases PT were from 16.5 to 24 seconds,PTR 1.29-1.88,INR 1.50-2. 501the monitoring interval days were from 3 to 138 days,of 84.7% eases the interval time was from 11 to 70 days. The complication were 3 cases of cerebral embolism, 8 cases of bleeding,2 eases of cutaneous pruritus and erythra. Conclusions PT showed excellent clinical application value for monitoring oral-taking warfarin after the operation of heart value prosthesis. The best criterion of anti-coagulation is INR 2.0± 0.5. The best interval time of monitoring PT is 30 days after the discharge of the patient and his INR remains stable.

关 键 词：凝血酶原时间 华法林 监测 心脏机械瓣膜 

分 类 号：R446.11[医药卫生—诊断学] R457.1[医药卫生—临床医学]