抑郁首发的双相心境障碍与反复发作抑郁的回顾性对照研究  

Retrospective comparison study of bipolar mood disorder with first onset of depression and recurrent depression

作　　者：金卫东[1] 陈炯[1] 邢保平[1] 唐贤祥[1] 陈震[1] 徐乐平[2] 李宁[2] 王勇[3] 

机构地区：[1]浙江省立同德医院,浙江省精神卫生研究院,杭州310012 [2]全军精神卫生中心 [3]辽宁鞍钢精神康复医院

出　　处：《中国行为医学科学》2007年第1期33-34,共2页Chinese Journal of Behavioral Medical Science

基　　金：浙江省卫生厅医药科技卫生研究基金项目（20038024）

摘　　要：目的 研究抑郁转向躁狂的相关因素及其危险程度，建立以抑郁为首发症状的双相障碍患者（软双相）的特征因素。方法对98例软双相进行回顾性调查并与55例反复发作抑郁症对照比较。结果 软双相患者年龄和发病年龄显著小于反复发作者、病程短于对照组，已婚者比例少，个性外向者比例高，文化程度显著高于反复发作患者，家族史阳性率高，OR界于1．07～15．17。临床特征方面，首次发作小于3个月、严重程度大于3分、精神病性、生物症状明显多于对照组，OR界于1．17-112．91之间。而用过3种药物者明显少于对照，回归分析提示，病程短、发病年龄早、个性外向、血缘近的阳性家族史、首次病程短于3个月、生物症状多都是促进疾病转相的危险因素。结论 软双相病人有自身的人文和临床特征，这些特征可能是促进软双相病人向双相转化的危险因素。Objective To study the risk and OR of depression shifting to mania. Method The retrospective comparison was made between 98 patients of soft bipolar disorder （bipolar depression before switching ） with first onset of depression and 55 patients with recurrent depression. Results The bipolar disorder before switching are named as soft bipolarity. Compared to recurrent depression , the patients with soft bipolarity are characterized by younger age and onset age, shorter duration of illness, lower married rate and more extroversion personality, higher positive rate of family history （ OR = 1.07 - 15.17 ）, higher rate of brief duration of depression episode 〈 3 months, more severe depressive symptoms 〉 3 scale, more psychotic, more biological symptoms and lower rate of suing rate of 3 antidepressants taken （OR = 1.17 - 112.9）. The regression analysis suggest that younger onset age, shorter duration of illness, extroversion personality, family history, brief duration of first depression episode 〈 3 months, more biological symptoms are risks that promote switching of disorder. Conclusion The soft bipolarity have the traits, which promote switching.

关 键 词：软双相 反复发作抑郁 危险因素 

分 类 号：R686[医药卫生—骨科学]