胡蜂蜂毒肽Mastoparan的研究概况  

A General Survey of the Study of Mastoparan(MP) from Wasp Venom

作　　者：和七一[1] 余晓东[1] 

机构地区：[1]重庆师范大学生命科学学院重庆市动物生物学重点实验室,重庆400047

出　　处：《重庆师范大学学报（自然科学版）》2007年第1期76-80,共5页Journal of Chongqing Normal University:Natural Science

基　　金：重庆师范大学科研基金重点项目(956207)

摘　　要：胡蜂毒液中存在多种活性物质,经蛰刺后进入动物机体,往往造成剧痛、水肿、局部损伤等一系列生理病理反应。阳离子十四肽m astoparan(MP)是胡蜂毒液中极为重要的一个组份,它具有诱导肥大细胞脱颗粒释放组胺,激活G蛋白、磷脂酶C(PLC)、磷脂酶D(PLD)、磷脂酸酶A2(PLA2),改变胞内外Ca2+浓度等多种活性,可以应用于科学研究、抗原检测、临床治疗等多个领域。与MP家族其它成员在序列和构象上进行比较分析后,通过对其结构进行修饰加工,可以产生新的、特异性好的MP类似物。There are many kinds of active suhstances in wasp venom ,which would evoke a series of physiological and pathological reactions including pang,edema, local damage, etc. Cationic tetradecapeptide mastoparan is an important active factor from wasp venom which showed a variety of activities including activation of G-protein,phospholipase C（ PLC ） ,phospholipase D（ PLD） and phospholipase A2（PLA2 ）, the change of Ca^2＋ concentration in ceils as well as histamine release after inducing mast cell degranularion. Mastoparan can be applied to many fields including research,antigen-detection and clinical therapy and so on. Comparing mastoparan with others from MP families in sequence and confromation,we can develop new and specific mastoparan analogues by modifying its structure.

关 键 词：mastoparan(MP) 阳离子十四肽 G蛋白 胡蜂 蜂毒 

分 类 号：Q965.9[生物学—昆虫学] Q969.554.3