冷冻胚胎解冻移植264个周期临床分析  

A Retrospective Analysis of 264 Thawed Embryo Transfer Cycles

作　　者：魏春霞[1] 于丛一[1] 麦美琪[1] 李予[1] 古少君[1] 李翠明[1] 杨冬梓[1] 张清学[1] 

机构地区：[1]中山大学附属第二医院妇产科生殖中心,广东广州510120

出　　处：《中山大学学报（医学科学版）》2007年第1期101-104,共4页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：卫生部临床项目重点学科(2004年);广州市科技局重点科研项目(2004Z1-E0101)

摘　　要：【目的】探讨影响冷冻胚胎解冻移植妊娠率的因素。【方法】收集2001年11月到2006年1月264位病人在本中心进行冷冻胚胎解冻移植264个周期的资料,进行回顾分析。【结果】264个周期中有67个周期妊娠,周期妊娠率25.38%。妊娠组平均每次移植胚胎个数多于非妊娠组(2.84±0.57 vs 2.45±0.82,P<0.05),移植1个、2个、3个及以上冷冻解冻胚胎的妊娠率分别为9.38%、18.67%、38.22%,其中移植3个及以上胚胎者的妊娠率高于移植1个和2个胚胎者的妊娠率(P<0.05)。胚胎解冻后体外培养24h平均细胞数增长率≥50%者的妊娠率(34.43%)高于增长率<50%者(17.28%),P<0.05,至少移植一个胚胎细胞数在6细胞及以上的周期妊娠率明显高于移植胚胎细胞数小于6细胞的周期(35.85% vs 16.67%,P<0.05);移植Ⅰ级胚胎与Ⅱ级胚胎的妊娠率分别为35.26%、17.58%,P<0.05。新鲜移植周期妊娠者其冻融周期妊娠率为42.86%,而在新鲜移植周期未妊娠者其冻融周期妊娠率为28.31%,差异有显著性,P<0.05。自然周期、激素替代周期妊娠率分别为28.21%、21.30%,无统计学差异。LH峰日内膜厚度及类型无统计学差异。【结论】移植胚胎的个数、质量、发育潜能、原新鲜周期的结局影响冷冻胚胎移植能否妊娠。[Objective] To analyze the impact of a number of factors on the pregnancy rate of frozen/thawed embryo transfer. [Methods] A database was analyzed retrospectively concerning frozen/thawed embryo transfer cycles from November 2001 to January 2006 which covered 264 cycles in 264 patients.[Result]The pregnancies occurred in 67 cycles of all 264 cycles. The pregnancy rate per cycle was 25.38%. There was significant difference in the number of embryos transferred each cycle between pregnant and non-pregnant group （2.84±0.57 vs 2.45±0.82, P〈 0.05）. The pregnancy rate were 9.38%, 18.67%, and 38.22% in the cycles of transferred 1, 2, and no less than 3 embryos respectively （P〈 0.05）. The pregnancy rate was higher in those cycles which cells of embryos increased no less than 50 percent or which cells of embryos were no less than six cells at transfer. Those cycles that conception occurred in previous fresh cycles had high pregnancy rate （P〈 0.05）. The pregnancy rate were 28.21% and 21.30% in spontaneous cycles and HRT cycles respectively （P 〉0.05） .There was no significant difference of the endometrial thickness and the echogenic pattern on the day of LH surge between pregnant and non-pregnant group. [Conclusion] The pregnancy rate was associated with the number of embryos transferred, quality of embryos, potential of embryos development,outcome of previous fresh cycle.

关 键 词：胚胎冷冻 胚胎移植 妊娠 

分 类 号：R711.75[医药卫生—妇产科学]